Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Sep;9(10):785-788.
doi: 10.2217/imt-2017-0078.

Targeting the PSGL-1 pathway for immune modulation

Roberto Tinoco  1 , Linda M Bradley  1
Affiliations

Targeting the PSGL-1 pathway for immune modulation

Roberto Tinoco et al. Immunotherapy. 2017 Sep.
No abstract available

Keywords: LCMV; PSGL-1; checkpoint; coinhibitory; costimulatory; melanoma.

PubMed Disclaimer

Conflict of interest statement

Financial & competing interests disclosure

This work was supported by grants R01 AI06895, R21 CA209627, and the Melanoma Research Foundation 322189 to LM Bradley; and National Institutes of Health (NIH) Institutional Research and Academic Career Development Award (IRACDA) K12 GM068524 and a University of California San Diego (UCSD) Chancellor's Postdoctoral fellowship to R Tinoco. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.

References

    1. Tinoco R, Otero DC, Takahashi AA, Bradley LM. PSGL-1: a new player in the immune checkpoint landscape. Trends Immunol. 2017;38(5):323–335. - PMC - PubMed
    1. Goetz DJ, Greif DM, Ding H, et al. Isolated P-selectin glycoprotein ligand-1 dynamic adhesion to P- and E-selectin. J. Cell Biol. 1997;137(2):509–519. - PMC - PubMed
    1. Spertini O, Cordey AS, Monai N, Giuffre L, Schapira M. P-selectin glycoprotein ligand 1 is a ligand for L-selectin on neutrophils, monocytes and CD34+ hematopoietic progenitor cells. J. Cell Biol. 1996;135(2):523–531. - PMC - PubMed
    1. Xia L, Ramachandran V, Mcdaniel JM, Nguyen KN, Cummings RD, Mcever RP. N-terminal residues in murine P-selectin glycoprotein ligand-1 required for binding to murine P-selectin. Blood. 2003;101(2):552–559. - PubMed
    1. Veerman KM, Williams MJ, Uchimura K, et al. Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs. Nat. Immunol. 2007;8(5):532–539. - PubMed

Publication types