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Case Reports
. 2017 Aug 30:4:e106.
doi: 10.14309/crj.2017.106. eCollection 2017.

Common Variable Immunodeficiency with Several Gastrointestinal Manifestations

Catarina Atalaia-Martins  1 , Sandra Barbeiro  1 , Pedro Marcos  1 , Isabel Cotrim  1 , Helena Vasconcelos  1
Affiliations
Case Reports

Common Variable Immunodeficiency with Several Gastrointestinal Manifestations

Catarina Atalaia-Martins et al. ACG Case Rep J. .

Abstract

Common variable immunodeficiency (CVID) is an immunodeficiency disorder with a high incidence of gastrointestinal (GI) manifestations and an increased risk of gastric malignancy. We report a case of a CVID with mild anemia presenting with multiple GI manifestations: gastric low-grade dysplasia (LGD), enteropathy with villous atrophy, refractory Giardia infection, nodular lymphoid hyperplasia, and inflammatory bowel-like disease. The differential diagnosis with celiac sprue could be challenging because of CVID enteropathy with villous flattening. Gastric LGD in a patient with an increased risk for gastric malignancy makes the appropriate surveillance of gastric cancer in CVID challenging.

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Figures

Figure 1
Figure 1
Duodenal villous blunting with ecchymotic areas.
Figure 2
Figure 2
Giardia lamblia in duodenal biopsy specimens.
Figure 3
Figure 3
Micronodular ileal pattern in terminal ileoscopy.
Figure 4
Figure 4
(A) Micronodular duodenal pattern on capsule endoscopy. (B) Ileal ulcers on capsule endoscopy.
See this image and copyright information in PMC

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