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. 2015 Dec;15(4):201-205.
doi: 10.17245/jdapm.2015.15.4.201. Epub 2015 Dec 31.

Articaine (4%) with epinephrine (1:100,000 or 1:200,000) in inferior alveolar nerve block: Effects on the vital signs and onset, and duration of anesthesia

Esshagh Lasemi  1 , Mehdi Sezavar  1 , Leyla Habibi  2 , Seyfollah Hemmat  3 , Farzin Sarkarat  1 , Zahra Nematollahi  4
Affiliations

Articaine (4%) with epinephrine (1:100,000 or 1:200,000) in inferior alveolar nerve block: Effects on the vital signs and onset, and duration of anesthesia

Esshagh Lasemi et al. J Dent Anesth Pain Med. 2015 Dec.

Abstract

Background: This prospective, randomized, double-blind, clinical study was conducted to compare the effects of 4% articaine with 1:100,000 epinephrine (A100) and 4% articaine with 1:200,000 epinephrine (A200) on the vital signs and onset and duration of anesthesia in an inferior alveolar nerve block (IANB).

Methods: In the first appointment, an IANB was performed by injecting A100 or A200 in 1 side of the mouth (right or left) randomly in patients referred for extraction of both their first mandibular molars. In the second appointment, the protocol was repeated and the other anesthetic solution was injected in the side that had not received the block in the previous session. Systolic and diastolic blood pressures (SBP and DBP) and pulse rate were measured during and 5 min after the injection. The onset and duration of anesthesia were also evaluated. Data were analyzed using t-test and Mann-Whitney U-test, and p-value was set at 0.05.

Results: SBP and pulse rate changes were slightly more with A100; however, DBP changes were more with A200, although the differences were not significant (P > 0.05). There were no statistically significant differences in the parameters evaluated in this study. The onset and duration of anesthesia, and the changes in SBP, DBP, and pulse rate during and 5 min after the injection were the same in both the groups.

Conclusions: For an IANB, A200 and A100 were equally efficient and successful in producing the block. Epinephrine concentration did not influence the effects of 4% articaine.

Keywords: Alveolar nerve, inferior; Articaine; Epinephrine; Local anesthetics; Vital signs.

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Conflict of interest statement

Competing Interests: The authors deny any conflicts of interest related to this study.

References

    1. Haas DA, Lennon D. Local anesthetic use by dentists in Ontario. J (Can Dent Assoc) 1995;61:297–304. - PubMed
    1. Palm A, Kirkegaard U, Poulsen S. The wand versus traditional injection for mandibular nerve block in children and adolescents: perceived pain and time of onset. Pediatr Dent. 2004;26:481–484. - PubMed
    1. Doan D. Comparison of Injection Discomfort and Anesthetic Duration of Plain Polocaine versus Epinephrine containing Articaine and Lidocaine. 2013.
    1. Pereira LA, Groppo FC, Bergamaschi Cde C, Meechan JG, Ramacciato JC, Motta RH. Articaine (4%) with epinephrine (1: 100,000 or 1: 200,000) in intraosseous injections in symptomatic irreversible pulpitis of mandibular molars: anesthetic efficacy and cardiovascular effects. Oral Surg Oral Med Oral Pathol Oral Radiol. 2013;116:e85–e91. - PubMed
    1. Yapp KE, Hopcraft MS, Parashos P. Articaine: a review of the literature. Br Dent J. 2011;210:323–329. - PubMed