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Clinical Trial
. 2017 Dec;106(6):794-800.
doi: 10.1007/s12185-017-2315-0. Epub 2017 Sep 6.

Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma

Marta Bielska  1 , Maciej Borowiec  2 , Dorota Jesionek-Kupnicka  3 , Marcin Braun  1   3   4 , Marcin Bojo  5 , Agata Pastorczak  1 , Ewa Kalinka-Warzocha  5 , Monika Prochorec-Sobieszek  6 , Tadeusz Robak  7 , Krzysztof Warzocha  8 , Wojciech Młynarski  9 , Ewa Lech-Marańda  8   10
Affiliations
Clinical Trial

Polymorphism in IKZF1 gene affects clinical outcome in diffuse large B-cell lymphoma

Marta Bielska et al. Int J Hematol. 2017 Dec.

Abstract

IKZF1 encodes a transcription factor involved in B-cell maturation and differentiation. We genotyped 218 diffuse large B-cell lymphoma (DLBCL) patients and 715 unrelated controls using a TaqMan allelic discrimination assay. No statistical difference was observed in the genotype distribution of the IKZF1 rs4132601 polymorphism between DLBCL patients and controls. However, the 2-year PFS rate of patients with the IKZF1 TT genotype was 54.3% compared to 68.6% in those with the IKZF1 G+ genotypes. Moreover, the IKZF1 rs4132601 polymorphism retained its independent prognostic impact on PFS. A more pronounced effect of the IKZF1 TT genotype on PFS was detected in patients with low/intermediate low IPI-risk group. When analysis was restricted to patients with GCB-type pattern, those with the IKZF1 TT genotype achieved a lower 5-year OS rate than the patients with the IKZF1 G+ genotypes (19.6 vs. 56%). This study provides the first evidence for the association of IKZF1 variants with DLBCL outcome.

Keywords: Diffuse large B-cell lymphoma; Gene polymorphism; IKZF1.

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