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. 1987 Aug;12(8):745-9.
doi: 10.1007/BF00970531.

Aging: effect on ex-vivo benzodiazepine binding after a diazepam injection

H L Komiskey

Aging: effect on ex-vivo benzodiazepine binding after a diazepam injection

H L Komiskey. Neurochem Res. 1987 Aug.

Abstract

Ex vivo [3H]flunitrazepam receptor occupation was determined in the brain of young, mature and old male Fischer 344 rats after a single intravenous injection of a low dose of diazepam. The two benzodiazepine receptor subtypes or conformations (BZ1 and BZ2) were differentiated by the displacement of [3H]flunitrazepam specific binding with the triazolopyridazine, CL 218,872. The acute diazepam injection decreased ex vivo [3H]flunitrazepam binding in only the senescent rats. The [3H]flunitrazepam binding at both the BZ1 and BZ2 receptor or receptor conformation was significantly reduced in the old rats.

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References

    1. Exp Neurol. 1979 Feb;63(2):347-55 - PubMed
    1. Neurobiol Aging. 1981 Summer;2(2):83-8 - PubMed
    1. Can Med Assoc J. 1978 Mar 4;118(5):513-4 - PubMed
    1. J Comp Neurol. 1955 Apr;102(2):511-6 - PubMed
    1. Brain Res. 1979 Jun 8;168(3):485-92 - PubMed

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