Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Mar;285(6):1024-1029.
doi: 10.1111/febs.14260. Epub 2017 Sep 21.

How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease

Anja Basters  1 , Klaus-Peter Knobeloch  1 , Günter Fritz  1
Affiliations
Free article
Review

How USP18 deals with ISG15-modified proteins: structural basis for the specificity of the protease

Anja Basters et al. FEBS J. 2018 Mar.
Free article

Abstract

The ubiquitin-specific protease 18 (USP18) has two major functions: (a) it is a highly specific protease that cleaves the ubiquitin-like modifier ISG15 (interferon-stimulated gene 15) from proteins, and (b) independent from its enzymatic activity USP18 interacts with the type I interferon receptor and shuts off downstream signaling. The structures of USP18 and a USP18-ISG15 complex revealed the molecular basis of the unique specificity of the protease and might shed some light into its interaction with the interferon receptor.

Keywords: ISG15; USP; cysteine protease; interferon.

PubMed Disclaimer

LinkOut - more resources