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Comment
. 2017 Jul 1;158(7):2074-2076.
doi: 10.1210/en.2017-00447.

Female Fertility: It Takes Two to Tango

Lucy X Chen  1 , Patricia T Jimenez  1
Affiliations
Comment

Female Fertility: It Takes Two to Tango

Lucy X Chen et al. Endocrinology. .
No abstract available

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Figures

Figure 1.
Figure 1.
Proposed molecular pathways by which granulosa cell IGF1R and FSHR collaborate to generate follicular maturity. AKT phosphorylation requires both IGF1R and FSHR activation and is essential for granulosa cell differentiation, proliferation, and survival. More importantly, failure of IGF1R to phosphorylate AKT inhibits advancement of folliculogenesis. cAMP, cyclic adenosine monophosphate; CREB, cAMP response element binding protein; ERK, extracellular signal-regulated kinase; GC, granulosa cell; mTOR, mechanistic target of rapamycin; P, phosphorylation; PI3K, phosphoinositide 3-kinase; PIP3, phosphatidylinosiitol (3,4,5)-triphosphate; PKA, protein kinase A.
See this image and copyright information in PMC

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References

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