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Case Reports
. 2017 Oct:217:175-176.
doi: 10.1016/j.ejogrb.2017.07.024. Epub 2017 Aug 4.

Successful management of a severe anti-M alloimmunization during pregnancy

Corinne Hubinont  1 , Gilda Delens  2 , Julie Vanalbada De Haan Hettema  2 , Catherine Lambert  3 , Christian Debauche  4 , Jean-Marc Biard  2
Affiliations
Case Reports

Successful management of a severe anti-M alloimmunization during pregnancy

Corinne Hubinont et al. Eur J Obstet Gynecol Reprod Biol. 2017 Oct.

Abstract

We report the successful outcome of a patient with anti-M antibodies with a previous history of severe hemolysis of erythrocytes. Serial plasma exchange from the first trimester combined with ultrasound monitoring of the fetal middle cerebral artery blood velocity was implemented. This management allowed a favorable pregnancy outcome of an infant born by an elective caesarean section at 32 weeks 6/7 with a normal Apgar score at 8/9/10. The other therapeutic alternatives such as intravenous immunoglobulin and in utero fetal blood transfusions are discussed.

Keywords: Anti-M antibodies; Hemolytic disease of the fetus and newborn; Plasmapheresis.

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