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Randomized Controlled Trial
. 2017 Sep 6;7(9):e015958.
doi: 10.1136/bmjopen-2017-015958.

Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol

Bindi Borg  1 , Seema Mihrshahi  1 , Mark Griffin  2 , Chhoun Chamnan  3 , Arnaud Laillou  4 , Frank T Wieringa  5
Affiliations
Randomized Controlled Trial

Crossover trial to test the acceptability of a locally produced lipid-based nutrient supplement (LNS) for children under 2 years in Cambodia: a study protocol

Bindi Borg et al. BMJ Open. .

Abstract

Introduction: The acceptability and efficacy of existing ready-to-use supplementary and therapeutic foods has been low in Cambodia, thus limiting success in preventing and treating malnutrition among Cambodian children. In that context, UNICEF and IRD have developed a locally produced, multiple micronutrient fortified lipid-based nutrient supplement. This food is innovative, in that it uses fish instead of milk as the animal source food. Very few supplementary foods have non-milk animal source foods, and in addition they have not been widely tested. This trial will assess the novel food's acceptability to children and caregivers.

Methods and analysis: This is a cluster-randomised, incomplete block, 4×4 crossover design with no blinding. It will take place in four sites in a community setting in periurban Phnom Penh. Healthy children aged 9-23 months (n=100) will eat each of four foods for 3 days at a time. The amount they consume will be measured, and at the end of each 3-day set, caregivers will assess how well their child liked the food. After 12 days, caregivers themselves will do a sensory test of the 4 foods and will rank them in terms of preference.

Ethics and dissemination: Ethical clearance was received from the University of Queensland Medical Research Ethics Committee (2014001070) and from Cambodia's National Ethics Committee for Health Research (03/8 NECHR).

Registration: ClinicalTrials.gov, identifier: LNS-CAMB-INFANTS; NCT02257437. Pre-results.

Keywords: Lipid-based nutrient supplement (LNS); acceptability; hedonic scale; micronutrient powder; ready-to-use supplementary food (RUSF); test feeding.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Food sequence schedule. CSB++, corn-soy blend++; LNS, lipid-based nutrient supplement.
See this image and copyright information in PMC

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