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. 2017 Sep-Oct;31(5):925-930.
doi: 10.21873/invivo.11148.

Parathyroid Carcinoma in Patients that Have Undergone Surgery for Primary Hyperparathyroidism

Petr Libánský  1 , Svatopluk Adámek  1 , Petr Broulík  2 , Martina Fialová  1 , Josef Kubinyi  3 , Robert Lischke  1 , Ondřej Naňka  4 , Pavel Pafko  1 , Jiří Šedý  5 , Vladimír Bobek  6   7   8   9
Affiliations

Parathyroid Carcinoma in Patients that Have Undergone Surgery for Primary Hyperparathyroidism

Petr Libánský et al. In Vivo. 2017 Sep-Oct.

Abstract

Background/aim: Parathyroid carcinoma is a rare clinical entity, which represents one of the main reasons, why surgery should be performed in specialized centres. Preoperatively, it is very difficult to distinguish between benign and malignant hyperparathyroidism.

Patients and methods: During the years 1996-2016, we performed 2,220 operations in 2,075 patients with a diagnosis of primary hyperparathyroidism.

Results: Among these 2,220 operations, there were 16 operations for parathyroid carcinoma. These 16 operations, including reoperations, were performed in four patients. Two patients had no reoperation, but another 2 patients required 14 reoperations in total. Parathyroid carcinoma was described in 0.2% of all patients with a diagnosis of primary hyperparathyroidism. The number of operations was 0.73% of all operations of primary hyperparathyroidism in years 1996-2016.

Conclusion: Prognosis of parathyroid carcinoma is quite favourable, patients evidence a long-term survival rate after the primary operation. However, every reoperation increases the number of possible complications, including recurrent laryngeal nerve injury.

Keywords: Parathyroid carcinoma; hyperparathyroidism; surgery.

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Figures

Figure 1
Figure 1. Lower right hyperplastic parathyroid gland, evaluated as a parathyroid adenoma, indicated to surgical removal
Figure 2
Figure 2. Reoperation in patient from Figure 1. Relapse is present on the neck, in upper mediastinum, with the necessity of partial sternotomy
Figure 3
Figure 3. Removed tumour from the approach that included the partial sternotomy. Patient from Figures 1 and 2
See this image and copyright information in PMC

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