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Review
. 2017 Aug 23:12:1339-1345.
doi: 10.2147/CIA.S141265. eCollection 2017.

Vascular aging and subclinical atherosclerosis: why such a "never ending" and challenging story in cardiology?

Stela Iurciuc  1   2 , Anca Maria Cimpean  3 , Florin Mitu  4 , Rodica Heredea  5 , Mircea Iurciuc  1   2
Affiliations
Review

Vascular aging and subclinical atherosclerosis: why such a "never ending" and challenging story in cardiology?

Stela Iurciuc et al. Clin Interv Aging. .

Abstract

The true onset of atherosclerosis remains one of the biggest challenges for cardiologists. Is atheroma plaque development considered the earliest step of vascular aging? If so, when it starts? Before or after birth? If it starts before birth or early during childhood, it seems that Thomas Sydenham was right: "A man is as old as his arteries." Except disorganization of elastic fibers, less is known about the morphology of vascular aging and also about the molecular events influencing the age of arteries, arterial stiffness, and their role in the appearance of future complications. Cellular and molecular events responsible for the switch from physiologic to pathologic aging of human arteries are less known. Epigenetic, genetic, and environmental influences at the onset of early vascular aging (EVA) should specifically influence the process. This paper briefly reviews the controversial data regarding vascular aging with an emphasis on the less known facts about the morphology of EVA.

Keywords: arterial aging; arterial stiffness; blood pressure variability; telomeres.

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Conflict of interest statement

Disclosure The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Aorta of 1-day-old human neonate showing macroscopically detected fatty streaks (A) certified as having the disorganization of elastic fibers (B, inset, orcein stain, ×400) and lipid accumulation.
See this image and copyright information in PMC

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