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Review
. 2016 Nov 28:2:25.
doi: 10.1186/s40794-016-0042-9. eCollection 2016.

Are you PEPped and PrEPped for travel? Risk mitigation of HIV infection for travelers

D M Brett-Major  1   2   3 , P T Scott  2 , T A Crowell  1   2 , C S Polyak  1   2 , K Modjarrad  1   2 , M L Robb  1   2 , D L Blazes  3   4
Affiliations
Review

Are you PEPped and PrEPped for travel? Risk mitigation of HIV infection for travelers

D M Brett-Major et al. Trop Dis Travel Med Vaccines. .

Abstract

The HIV pandemic persists globally and travelers are at risk for infection by the Human Immunodeficiency Virus (HIV). While HIV-focused guidelines delineate risk stratification and mitigation strategies for people in their home communities, travel issues are not addressed. In this review, direct and indirect evidence on HIV risk among travelers is explored. The burgeoning practice of employing pre-exposure prophylaxis (PrEP) with anti-retroviral therapy in the non-travel setting is introduced, as well as the more established use of post-exposure prophylaxis (PEP). Challenges in applying these lessons to travelers are discussed, and a new guidelines process is scoped and recommended.

Keywords: Human Immunodeficiency Virus; Post-exposure; Pre-exposure; Prophylaxis; Review; Travel.

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Fig. 1
Mechanisms of anti-HIV activity by drug class
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