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Review
. 2017 Mar 24:3:6.
doi: 10.1186/s40794-017-0050-4. eCollection 2017.

Prospecting for an HIV vaccine

D M Brett-Major  1   2 , T A Crowell  1   2 , N L Michael  1
Affiliations
Review

Prospecting for an HIV vaccine

D M Brett-Major et al. Trop Dis Travel Med Vaccines. .

Abstract

Human immunodeficiency virus (HIV) sets several challenges for the development of a preventative HIV vaccine. Predictable, protective natural immunity against HIV does not occur and so unlike most other diseases for which vaccines exist, there are few guideposts from natural infection. Nonetheless, six vaccine efficacy trials have occurred. One in particular, the Thai trial called RV144, showed partial protective efficacy and potential ways ahead to a better vaccine approach. This coupled with other lessons from studies of acute infections as well as an increasingly complex knowledge of HIV-related vaccine immunology bring hope that a vaccine solution might be reached for this pervasive and deadly pandemic.

Keywords: Human immunodeficiency virus vaccine protective efficacy immunology review.

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