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Review
. 2017 Mar 24:3:6.
doi: 10.1186/s40794-017-0050-4. eCollection 2017.

Prospecting for an HIV vaccine

D M Brett-Major  1   2 , T A Crowell  1   2 , N L Michael  1
Affiliations
Review

Prospecting for an HIV vaccine

D M Brett-Major et al. Trop Dis Travel Med Vaccines. .

Abstract

Human immunodeficiency virus (HIV) sets several challenges for the development of a preventative HIV vaccine. Predictable, protective natural immunity against HIV does not occur and so unlike most other diseases for which vaccines exist, there are few guideposts from natural infection. Nonetheless, six vaccine efficacy trials have occurred. One in particular, the Thai trial called RV144, showed partial protective efficacy and potential ways ahead to a better vaccine approach. This coupled with other lessons from studies of acute infections as well as an increasingly complex knowledge of HIV-related vaccine immunology bring hope that a vaccine solution might be reached for this pervasive and deadly pandemic.

Keywords: Human immunodeficiency virus vaccine protective efficacy immunology review.

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References

    1. HIV/AIDS Fact Sheet. World Health Organization, Geneva. 2015. http://www.who.int/mediacentre/factsheets/fs360/en/. Accessed 10 Jul 2016.
    1. Jamieson D, Kellerman SE. The 90 90 90 strategy to end the HIV Pandemic by 2030: Can the supply chain handle it? J Int AIDS Soc. 2016;19(1):20917. doi: 10.7448/IAS.19.1.20917. - DOI - PMC - PubMed
    1. Smith JA, Anderson SJ, Harris KL, McGillen JB, Lee E, Garnett GP, Hallett TB. Maximising HIV prevention by balancing the opportunities of today with the promises of tomorrow: a modelling study. Lancet HIV. 2016;3(7):e289–296. doi: 10.1016/S2352-3018(16)30036-4. - DOI - PMC - PubMed
    1. Crowell TA, Hatano H. Clinical outcomes and antiretroviral therapy in ‘elite’ controllers: a review of the literature. J Virus Erad. 2015;1(2):72–77. - PMC - PubMed
    1. Sheng Z, Schramm CA, Connors M, Morris L, Mascola JR, Kwong PD, Shapiro L. Effects of Darwinian selection and mutability on rate of broadly neutralizing antibody evolution during HIV-1 infection. PLoS Comput Biol. 2016;12(5):e1004940. doi: 10.1371/journal.pcbi.1004940. - DOI - PMC - PubMed

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