Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2017 Jul 12;3(3):FSO217.
doi: 10.4155/fsoa-2017-0018. eCollection 2017 Aug.

Reconceptualizing cancer immunotherapy based on plant production systems

Kathleen Hefferon  1
Affiliations
Review

Reconceptualizing cancer immunotherapy based on plant production systems

Kathleen Hefferon. Future Sci OA. .

Abstract

Plants can be used as inexpensive and facile production platforms for vaccines and other biopharmaceuticals. More recently, plant-based biologics have expanded to include cancer immunotherapy agents. The following review describes the current state of the art for plant-derived strategies to prevent or reduce cancers. The review discusses avenues taken to prevent infection by oncogenic viruses, solid tumors and lymphomas. Strategies including cancer vaccines, monoclonal antibodies and virus nanoparticles are described, and examples are provided. The review ends with a discussion of the implications of plant-based cancer immunotherapy for developing countries.

Keywords: antibody; cancer immunotherapy; oncovirus; plant virus nanoparticle; transgenic plant.

PubMed Disclaimer

Conflict of interest statement

Financial & competing interests disclosure The author has no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.

Figures

<b>Figure 1.</b>
Figure 1.. Different types of biopharmaceutical expression strategies utilizing plant-based production systems.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Ferlay J, Soerjomataram I, Ervik M, et al. GLOBOCAN (2012). v1.0, Cancer Incidence and Mortality Worldwide: IARC CancerBase No. 11. International Agency for Research on Cancer; Lyon, France: 2013. http://globocan.iarc.fr
    1. Bray F, Ren JS, Masuyer E, Ferlay J. Estimates of global cancer prevalence for 27 sites in the adult population in (2008) Int. J. Cancer. 2013;132(5):1133–1145. - PubMed
    1. Waldmann TA. Immunotherapy: past, present and future. Nat. Med. 2003;9(3):269–277. - PubMed
    1. Yusibov V, Streatfield SJ, Kushnir N. Clinical development of plant-produced recombinant pharmaceuticals: vaccines, antibodies and beyond. Hum. Vaccin. 2011;7(3):313–321. - PubMed
    1. Sainsbury F, Lomonossoff GP. Transient expressions of synthetic biology in plants. Curr. Opin. Plant Biol. 2014;19:1–7. - PMC - PubMed

LinkOut - more resources