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Review
. 2017 Nov;29(6):443-447.
doi: 10.1097/CCO.0000000000000411.

Put away your microscopes: the ependymoma molecular era has begun

Stephen C Mack  1 , Michael D Taylor
Affiliations
Review

Put away your microscopes: the ependymoma molecular era has begun

Stephen C Mack et al. Curr Opin Oncol. 2017 Nov.

Abstract

Purpose of review: To synthesize, integrate, and comment on recent research developments to our understanding of the molecular basis of ependymoma (EPN), and to place this in context with current treatment and research efforts.

Recent findings: Our recent understanding of the histologically defined molecular entity EPN has rapidly advanced through genomic, transcriptomic, and epigenomic profiling studies.

Summary: These advancements lay the groundwork for development of future EPN biomarkers, models, and therapeutics. Our review discusses these discoveries and their impact on our clinical understanding of this disease. Lastly, we offer insight into clinical and research areas requiring further validation, and open questions remaining in the field.

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Conflict of interest statement

CONFLICTS OF INTEREST

None

Figures

Figure 1
Figure 1
Summary of intracranial ependymoma subgroups and recommendations for future ependymoma clinical trials. Adapted from the Ependymoma Consensus Meeting manuscript[10].
See this image and copyright information in PMC

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