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Comment
. 2017 Sep;84(9):681-686.
doi: 10.3949/ccjm.84a.14129.

Renal denervation: What happened, and why?

Mehdi H Shishehbor  1   2   3   4   5 , Tarek A Hammad  6 , George Thomas  7   8   9
Affiliations
Free article
Comment

Renal denervation: What happened, and why?

Mehdi H Shishehbor et al. Cleve Clin J Med. 2017 Sep.
Free article

Abstract

Despite promising results in initial trials, renal denervation failed to achieve its efficacy end points as a treatment for resistant hypertension in the SYMPLICITY HTN-3 trial, the largest trial of this treatment to date (N Engl J Med 2014; 370:1393-1401). Is renal denervation dead, or will future trials and newer technology revive it?

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Comment in

  • Renal denervation: Are we on the right path?
    Denktas AE, Paniagua D, Jneid H. Denktas AE, et al. Cleve Clin J Med. 2017 Sep;84(9):687-689. doi: 10.3949/ccjm.84a.17024. Cleve Clin J Med. 2017. PMID: 28885900 No abstract available.

Comment on

  • A controlled trial of renal denervation for resistant hypertension.
    Bhatt DL, Kandzari DE, O'Neill WW, D'Agostino R, Flack JM, Katzen BT, Leon MB, Liu M, Mauri L, Negoita M, Cohen SA, Oparil S, Rocha-Singh K, Townsend RR, Bakris GL; SYMPLICITY HTN-3 Investigators. Bhatt DL, et al. N Engl J Med. 2014 Apr 10;370(15):1393-401. doi: 10.1056/NEJMoa1402670. Epub 2014 Mar 29. N Engl J Med. 2014. PMID: 24678939 Clinical Trial.

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