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. 2017 Sep 7;21(3):289-290.
doi: 10.1016/j.stem.2017.08.017.

Putting Two Heads Together to Build a Better Brain

John K Mich  1 , Jennie L Close  1 , Boaz P Levi  2
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Putting Two Heads Together to Build a Better Brain

John K Mich et al. Cell Stem Cell. .
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Abstract

3D organoids enable in vitro human brain development models, but they have not yet recapitulated some essential features of brain circuit formation. Recently, several studies appearing in Nature, Nature Methods, and Cell Stem Cell generated fused organoid models of inhibitory and excitatory neuron development, which can now achieve functional circuit integration.

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