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Comment
. 2017 Sep 7;21(3):291-292.
doi: 10.1016/j.stem.2017.08.004.

Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML

Laura MacPherson  1 , Mark A Dawson  2
Affiliations
Free article
Comment

Survival of the Fittest: Darwinian Selection Underpins Chemotherapy Resistance in AML

Laura MacPherson et al. Cell Stem Cell. .
Free article

Abstract

Intratumor heterogeneity driving therapeutic resistance is a major challenge in cancer management. Recently in Nature, Shlush et al. (2017) provide a tour de force of genomics coupled to functional assays to demonstrate that resistance emerges from a pre-existing subpopulation of acute myeloid leukemia (AML) cells with a stem cell transcription program.

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  • Tracing the origins of relapse in acute myeloid leukaemia to stem cells.
    Shlush LI, Mitchell A, Heisler L, Abelson S, Ng SWK, Trotman-Grant A, Medeiros JJF, Rao-Bhatia A, Jaciw-Zurakowsky I, Marke R, McLeod JL, Doedens M, Bader G, Voisin V, Xu C, McPherson JD, Hudson TJ, Wang JCY, Minden MD, Dick JE. Shlush LI, et al. Nature. 2017 Jul 6;547(7661):104-108. doi: 10.1038/nature22993. Epub 2017 Jun 28. Nature. 2017. PMID: 28658204

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