Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Sep 7;21(3):293-294.
doi: 10.1016/j.stem.2017.08.005.

Hypothalamic Neurons Take Center Stage in the Neural Stem Cell Niche

Julia P Andreotti  1 , Luiza Lousado  1 , Luiz Alexandre V Magno  1 , Alexander Birbrair  2
Affiliations
Comment

Hypothalamic Neurons Take Center Stage in the Neural Stem Cell Niche

Julia P Andreotti et al. Cell Stem Cell. .

Abstract

Neural stem cells (NSCs) are a heterogeneous population of cells that generate new neurons in adult animals. Recently in Science, Paul et al. (2017) show that hypothalamic neurons control activation of a subset of NSCs in response to feeding, providing insights into how physiological cues may influence stem cell activation.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.. POMC-Expressing Neurons are a Key Component of the SVZ NSC Niche
The NSC niche is a specialized microenvironment that supports NSCs and provides them with behavioral cues. Paul et al. show that POMC+ neurons projecting from the hypothalamus are a key component of the anterior ventral portion of the SVZ NSC niche. Physiological manipulation of these POMC+ neurons via feeding and fasting leads to activation of a subset of NSCs and a consequent increase in production of a specific subtype of interneuron within the olfactory bulb.
See this image and copyright information in PMC

Comment on

References

    1. Birbrair A, and Frenette PS (2016). Ann. N Y Acad. Sci 1370, 82–96. - PMC - PubMed
    1. Doty RL, and Cameron EL (2009). Physiol. Behav 97, 213–228. - PMC - PubMed
    1. Fichna J, Janecka A, Costentin J, and Do Rego JC (2007). Pharmacol. Rev 59, 88–123. - PubMed
    1. Kim E, Clark AL, Kiss A, Hahn JW, Wes-selschmidt R, Coscia CJ, and Belcheva MM (2006). J. Biol. Chem 281, 33749–33760. - PMC - PubMed
    1. Lim DA, and Alvarez-Buylla A (2016). Cold Spring Harb. Perspect. Biol 8, 10.1101/cshperspect.a018820. - DOI - PMC - PubMed

LinkOut - more resources