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Comment
. 2017 Sep 7;21(3):295-296.
doi: 10.1016/j.stem.2017.08.007.

CRISPR: Established Editor of Human Embryos?

Xiao-Jiang Li  1 , Zhuchi Tu  2 , Weili Yang  2 , Shihua Li  3
Affiliations
Comment

CRISPR: Established Editor of Human Embryos?

Xiao-Jiang Li et al. Cell Stem Cell. .

Abstract

Off-target effects and mosaicism are major concerns for applying CRISPR-Cas9 to correct genetic mutations. A recent article in Nature by Ma et al. (2017) uses an elegant CRISPR-Cas9 approach that repairs a genetic mutation in human embryos with negligible mosaicism and no off-target effects, bringing this editing tool closer to clinical application.

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Comment on

  • Correction of a pathogenic gene mutation in human embryos.
    Ma H, Marti-Gutierrez N, Park SW, Wu J, Lee Y, Suzuki K, Koski A, Ji D, Hayama T, Ahmed R, Darby H, Van Dyken C, Li Y, Kang E, Park AR, Kim D, Kim ST, Gong J, Gu Y, Xu X, Battaglia D, Krieg SA, Lee DM, Wu DH, Wolf DP, Heitner SB, Belmonte JCI, Amato P, Kim JS, Kaul S, Mitalipov S. Ma H, et al. Nature. 2017 Aug 24;548(7668):413-419. doi: 10.1038/nature23305. Epub 2017 Aug 2. Nature. 2017. PMID: 28783728

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