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Comment
. 2017 Sep 7;170(6):1057-1059.
doi: 10.1016/j.cell.2017.08.033.

Crowd Control: E7 Conservation Is the Key to Cancer

Elizabeth A White  1 , Karl Munger  2
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Free article
Comment

Crowd Control: E7 Conservation Is the Key to Cancer

Elizabeth A White et al. Cell. .
Free article

Abstract

Several human papillomavirus type 16 (HPV16) oncoproteins contribute to cellular transformation in vitro. In this issue of Cell, Mirabello and colleagues use high-throughput sequencing data to assess the diversity of HPV16 isolates from human patients. These data suggest that the E7 oncoprotein is the fundamental contributor to in vivo carcinogenesis.

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  • HPV16 E7 Genetic Conservation Is Critical to Carcinogenesis.
    Mirabello L, Yeager M, Yu K, Clifford GM, Xiao Y, Zhu B, Cullen M, Boland JF, Wentzensen N, Nelson CW, Raine-Bennett T, Chen Z, Bass S, Song L, Yang Q, Steinberg M, Burdett L, Dean M, Roberson D, Mitchell J, Lorey T, Franceschi S, Castle PE, Walker J, Zuna R, Kreimer AR, Beachler DC, Hildesheim A, Gonzalez P, Porras C, Burk RD, Schiffman M. Mirabello L, et al. Cell. 2017 Sep 7;170(6):1164-1174.e6. doi: 10.1016/j.cell.2017.08.001. Cell. 2017. PMID: 28886384 Free PMC article.

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