Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2017 Sep 8;17(1):166.
doi: 10.1186/s12886-017-0562-8.

Internal limiting membrane peeling and gas tamponade for myopic foveoschisis: a systematic review and meta-analysis

Bo Meng  1 , Lu Zhao  1 , Yi Yin  1 , Hongyang Li  1 , Xiaolei Wang  1 , Xiufen Yang  1 , Ran You  1 , Jialin Wang  1 , Youjing Zhang  1 , Hui Wang  1 , Ran Du  1 , Ningli Wang  2 , Siyan Zhan  3 , Yanling Wang  4
Affiliations
Meta-Analysis

Internal limiting membrane peeling and gas tamponade for myopic foveoschisis: a systematic review and meta-analysis

Bo Meng et al. BMC Ophthalmol. .

Abstract

Background: Myopic foveoschisis (MF) is among the leading causes of visual loss in high myopia. However, it remains controversial whether internal limiting membrane (ILM) peeling or gas tamponade is necessary treatment option for MF.

Methods: PubMed, EMBASE, CBM, CNKI, WANFANG DATA and VIP databases were systematically reviewed. Outcome indicators were myopic foveoschisis resolution rate, visual acuity improvement and postoperative complications.

Results: Nine studies that included 239 eyes were selected. The proportion of resolution of foveoschisis was higher in ILM peeling group than non-ILM peeling group (OR = 2.15, 95% CI: 1.06-4.35; P = 0.03). The proportion of postoperative complications was higher in Tamponade group than non-Tamponade group (OR = 10.81, 95% CI: 1.26-93.02; P = 0.03). However, the proportion of visual acuity improvement (OR = 1.63, 95% CI: 0.56-4.80; P = 0.37) between ILM peeling group and non-ILM peeling group and the proportion of resolution of foveoschisis (OR = 1.80, 95% CI: 0.76-4.28; P = 0.18) between Tamponade group and non-Tamponade group were similar.

Conclusions: Vitrectomy with internal limiting membrane peeling could contribute to better resolution of myopic foveoschisis than non-peeling, however it does not significantly influence the proportion of visual acuity improvement and postoperative complications. Vitrectomy with gas tamponade is associated with more complications than non-tamponade and does not significantly influence the proportion of visual acuity improvement and resolution of myopic foveoschisis.

Keywords: Internal limiting membrane peeling; Myopic foveoschisis; Systematic review; Tamponade.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

Not applicable.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
a Flowchart of selection process in the comparison of ILM peeling group and non-ILM peeling group. b Flowchart of selection process in the comparison of Tamponade group and non-Tamponade group
Fig. 2
Fig. 2
a A forest plot showing the proportion of resolution of MF between ILM peeling group and non-ILM peeling group. b A forest plot showing the proportion of resolution of MF between Tamponade group and non-Tamponade group. Song①, Song②: two sets of data in the study of Song et al
Fig. 3
Fig. 3
A forest plot showing the proportion of visual acuity improvement between ILM peeling group and non-ILM peeling group
Fig. 4
Fig. 4
A forest plot showing the proportion of postoperative complications between Tamponade group and non-Tamponade group
Fig. 5
Fig. 5
Funnel plots of the included studies comparing the proportion of resolution of MF of retinal reattachment showing no significant publication bias. a ILM peeling group versus non-ILM peeling group. b Tamponade group versus non-Tamponade group. SE = standard error, OR = odds ratio
See this image and copyright information in PMC

References

    1. Valldeperas X, Lorenzo-Carrero J. Vitreous tamponades in highly myopic eyes. Biomed Res Int. 2014;2014:420380. doi: 10.1155/2014/420380. - DOI - PMC - PubMed
    1. Takano M, Kishi S. Foveal retinoschisis and retinal detachment in severely myopic eyes with posterior staphyloma. Am J Ophthalmol. 1999;128(4):472–476. doi: 10.1016/S0002-9394(99)00186-5. - DOI - PubMed
    1. Baba T, Ohno-Matsui K, Futagami S, Yoshida T, Yasuzumi K, Kojima A, et al. Prevalence and characteristics of foveal retinal detachment without macular hole in high myopia. Am J Ophthalmol. 2003;135(3):338–342. doi: 10.1016/S0002-9394(02)01937-2. - DOI - PubMed
    1. Henaine-Berra A, Zand-Hadas IM, Fromow-Guerra J, Garcia-Aguirre G. Prevalence of macular anatomic abnormalities in high myopia. Ophthalmic Surg Lasers Imaging Retina. 2013;44(2):140–144. doi: 10.3928/23258160-20130219-01. - DOI - PubMed
    1. Panozzo G, Mercanti A. Optical coherence tomography findings in myopic traction maculopathy. Arch Ophthalmol. 2004;122(10):1455–1460. doi: 10.1001/archopht.122.10.1455. - DOI - PubMed

LinkOut - more resources