Advances in macrocyclic peptide-based antibiotics

Abstract

Macrocyclic peptide-based natural products have provided powerful new antibiotic drugs, drug candidates, and scaffolds for medicinal chemists as a source of inspiration to design novel antibiotics. While most of those natural products are active mainly against Gram-positive pathogens, novel macrocyclic peptide-based compounds have recently been described, which exhibit potent and specific activity against some of the most problematic Gram-negative ESKAPE pathogens. This mini-review gives an up-date on recent developments.

Keywords: Antibiotics; Gram-negative ESKAPE pathogens; Macrocyclic peptides and depsipetides; Outer-membrane protein targeting antibiotics (OMPTA).