Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2018 Mar;168(3-4):62-66.
doi: 10.1007/s10354-017-0592-0. Epub 2017 Sep 8.

Intestinal microbiome-gut-brain axis and irritable bowel syndrome

Gabriele Moser  1 , Camille Fournier  2 , Johannes Peter  2
Affiliations
Review

Intestinal microbiome-gut-brain axis and irritable bowel syndrome

Gabriele Moser et al. Wien Med Wochenschr. 2018 Mar.

Abstract
in English, German

Psychological comorbidity is highly present in irritable bowel syndrome (IBS). Recent research points to a role of intestinal microbiota in visceral hypersensitivity, anxiety, and depression. Increased disease reactivity to psychological stress has been described too. A few clinical studies have attempted to identify features of dysbiosis in IBS. While animal studies revealed strong associations between stress and gut microbiota, studies in humans are rare. This review covers the most important studies on intestinal microbial correlates of psychological and clinical features in IBS, including stress, anxiety, and depression.

Psychische Komorbidität ist häufig bei Reizdarmsyndrom (RDS). Die aktuelle Forschung weist auf eine Rolle des intestinalen Mikrobioms bei der viszeralen Hypersensitivität, bei Angst und Depression hin. Eine Steigerung der Krankheitssymptomatik bei psychischem Stress wurde beschrieben. Wenige klinische Studien haben versucht, Muster einer Dysbiose für RDS zu identifizieren. Während Tierstudien eine starke Assoziation zwischen Stress und Darm-Mikrobiom aufdeckten, sind Studien beim Menschen rar. Diese Übersicht umfasst die wichtigsten Studien über Zusammenhänge zwischen dem intestinalen Mikrobiom und psychischen und klinischen Aspekten bei RDS, inklusive Stress, Angst und Depression.

Keywords: Anxiety; Depression; Enterotype; Psyche; Stress.

PubMed Disclaimer

Conflict of interest statement

G. Moser, C. Fournier, and J. Peter declare that they have no competing interests.

References

    1. Gill SR, Pop M, Deboy RT, et al. Metagenomic analysis of the human distal gut microbiome. Science. 2006;312(5778):1355–1359. doi: 10.1126/science.1124234. - DOI - PMC - PubMed
    1. Cho I, Blaser MJ. The human microbiome: at the interface of health and disease. Nat Rev Genet. 2012;13(4):260–270. doi: 10.1038/nrg3182. - DOI - PMC - PubMed
    1. Shreiner AB, Kao JY, Young VB. The gut microbiome in health and in disease. Curr Opin Gastroenterol. 2015;31(1):69–75. doi: 10.1097/MOG.0000000000000139. - DOI - PMC - PubMed
    1. Cryan JF, O’Mahony SM. The microbiome-gut-brain axis: from bowel to behavior. Neurogastroenterol Motil. 2011;23(3):187–192. doi: 10.1111/j.1365-2982.2010.01664.x. - DOI - PubMed
    1. Kennedy PJ, Cryan JF, Dinan TG, et al. Kynurenine pathway metabolism and the microbiota-gut-brain axis. Neuropharmacology. 2017;112(Pt B):399–412. doi: 10.1016/j.neuropharm.2016.07.002. - DOI - PubMed

LinkOut - more resources