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Review
. 2017 Aug:25:126-133.
doi: 10.1016/j.coviro.2017.08.005. Epub 2017 Sep 6.

Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections

Hannah L Itell  1 , Amitinder Kaur  2 , Jesse D Deere  3 , Peter A Barry  3 , Sallie R Permar  4
Affiliations
Review

Rhesus monkeys for a nonhuman primate model of cytomegalovirus infections

Hannah L Itell et al. Curr Opin Virol. 2017 Aug.

Abstract

Human cytomegalovirus (HCMV) is the leading opportunistic viral infection in solid organ transplant patients and is the most common congenitally transmitted pathogen worldwide. Despite the significant burden of disease HCMV causes in immunosuppressed patients and infected newborns, there are no licensed preventative vaccines or effective immunotherapeutic treatments for HCMV, largely due to our incomplete understanding of the immune correlates of protection against HCMV infection and disease. Though CMV species-specificity imposes an additional challenge in defining a suitable animal model for HCMV, nonhuman primate (NHP) CMVs are the most genetically related to HCMV. In this review, we discuss the advantages and applicability of rhesus monkey models for studying HCMV infections and pathogenesis and ultimately informing vaccine development.

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Conflict of interest statement

Conflict of Interest Statement

S.R.P., A.K., and P.A.B. provide consulting services to Pfizer Inc. for their preclinical HCMV vaccine program and associated animal models. The other authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Rhesus monkey placental tissue stained positively for RhCMV-IE1 protein. Placental tissue pictured was from two immunosuppressed seronegative dams. Adapted from Bialas et al., 2015 [87].
See this image and copyright information in PMC

Comment in

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