Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2017 Dec;14(12):954-956.
doi: 10.1038/cmi.2017.89. Epub 2017 Sep 11.

miR-31: a key player in CD8 T-cell exhaustion

Siddheshvar Bhela  1 , Barry T Rouse  1
Affiliations
Comment

miR-31: a key player in CD8 T-cell exhaustion

Siddheshvar Bhela et al. Cell Mol Immunol. 2017 Dec.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Model illustrating the role of miR-31 in CD8 T-cell biology during chronic viral infections. TCR and CD28 co-stimulation induces the upregulation of miR-31 in CD8 T cells. miR-31 promotes type 1 interferon signaling by targeting Ppp6C, a phosphatase that is a negative regulator of interferon signaling. Increased interferon signaling results in the increased expression of exhaustion genes and the decreased expression of effector genes, thus inducing an exhaustion phenotype. When miR-31 is knocked out in CD8 T cells, increased expression of Ppp6C reduces type 1 interferon and thus increases effector functionality.
See this image and copyright information in PMC

Comment on

References

    1. O'Connell RM, Rao DS, Chaudhuri AA, Baltimore D. Physiological and pathological roles for microRNAs in the immune system. Nat Rev Immunol 2010; 10: 111–122. - PubMed
    1. Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing. Cell 2008; 132: 9–14. - PubMed
    1. Thai TH, Calado DP, Casola S, Ansel KM, Xiao C, Xue Y et al. Regulation of the germinal center response by microRNA-155. Science 2007; 316: 604–608. - PubMed
    1. Bhela S, Mulik S, Reddy PB, Richardson RL, Gimenez F, Rajasagi NK et al. Critical role of microRNA-155 in herpes simplex encephalitis. J Immunol 2014; 192: 2734–2743. - PMC - PubMed
    1. Bhela S, Mulik S, Gimenez F, Reddy PB, Richardson RL, Varanasi SK et al. Role of miR-155 in the pathogenesis of herpetic stromal keratitis. Am J Pathol 2015; 185: 1073–1084. - PMC - PubMed

Publication types