Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2018 Jun;15(6):640-641.
doi: 10.1038/cmi.2017.93. Epub 2017 Sep 11.

Generating CD8αα IELs from two sources of thymic precursors

Lu Bai  1 , Hui Peng  2
Affiliations
Comment

Generating CD8αα IELs from two sources of thymic precursors

Lu Bai et al. Cell Mol Immunol. 2018 Jun.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The origin and development of intestinal CD8αα IELs. In the thymus, CD4 and CD8 double-negative (DN) thymocytes give rise to CD4 and CD8 double-positive (DP) thymocytes. Through positive selection, DP thymocytes further differentiate into CD8αβ+or CD4+ single-positive (SP) cells. DP thymocytes can also undergo alternative selection and downregulate the expression of CD4 and CD8, becoming the precursors of CD8αα IELs. There are two distinct subsets of CD8αα IEL precursors (IELps) in the thymus: one subset is PD1+T-bet− (type A IELps), which localizes to the thymic cortex and efficiently emigrates in an S1PR1-dependent manner, while the other is PD1−T-bet+ (type B IELps), which localizes to the thymic medulla and is less migration-competent.
See this image and copyright information in PMC

Comment on

References

    1. Cheroutre H, Lambolez F, Mucida D. The light and dark sides of intestinal intraepithelial lymphocytes. Nat Rev Immunol. 2011;11:445–456. doi: 10.1038/nri3007. - DOI - PMC - PubMed
    1. Camerini V, Panwala C, Kronenberg M. Regional specialization of the mucosal immune system. Intraepithelial lymphocytes of the large intestine have a different phenotype and function than those of the small intestine. J Immunol. 1993;151:1765–1776. - PubMed
    1. Sheridan BS, Lefrancois L. Intraepithelial lymphocytes: to serve and protect. Curr Gastroenterol Rep. 2010;12:513–521. doi: 10.1007/s11894-010-0148-6. - DOI - PMC - PubMed
    1. Klose CS, Blatz K, d'Hargues Y, Hernandez PP, Kofoed-Nielsen M, Ripka JF, et al. The transcription factor T-bet is induced by IL-15 and thymic agonist selection and controls CD8alphaalpha(+) intraepithelial lymphocyte development. Immunity. 2014;41:230–243. doi: 10.1016/j.immuni.2014.06.018. - DOI - PubMed
    1. Reis BS, Hoytema van Konijnenburg DP, Grivennikov SI, Mucida D. Transcription factor T-bet regulates intraepithelial lymphocyte functional maturation. Immunity. 2014;41:244–256. doi: 10.1016/j.immuni.2014.06.017. - DOI - PMC - PubMed

MeSH terms

Substances

LinkOut - more resources