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Review
. 2017;6(1):35-41.
doi: 10.1007/s13671-017-0168-7. Epub 2017 Jan 21.

Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma

Yuki M F Andersen  1 , Alexander Egeberg  1 , Lone Skov  1 , Jacob P Thyssen  1
Affiliations
Review

Comorbidities of Atopic Dermatitis: Beyond Rhinitis and Asthma

Yuki M F Andersen et al. Curr Dermatol Rep. 2017.

Erratum in

Abstract

Purpose of review: In this review article, we summarize the current evidence about atopic dermatitis (AD)-associated comorbidities, beyond the traditional atopic and allergic conditions.

Recent findings: Patients with AD may have an increased risk of cardiovascular diseases, certain malignancies, autoimmune diseases, and neuropsychiatric diseases. The causes of these associations are likely multifactorial and may include genetic predispositions, systemic low-grade inflammation, environmental exposures, medication, and lifestyle and behavioral risk factors. There appears to be geographical variations in prevalence of comorbidities in patients with AD, indicating that differences in ethnicity and lifestyle factors may significantly influence the risk of certain comorbidities.

Summary: The reported comorbidities in recent literature emphasize the burden of disease in patients with AD. Early appropriate AD therapy, in combination with reduction of risk factors, may help prevention of certain comorbidities. The reported observations may generate hypotheses for future investigations in underlying risk factors for AD-associated comorbidities.

Keywords: Atopic dermatitis; Autoimmune disease; Cancer; Cardiovascular disease; Comorbidities; Neuropsychiatric disease.

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Conflict of interest statement

Conflict of Interest

Jacob Thyssen and Yuki Andersen are supported by an unrestricted grant from the Lundbeck Foundation. Jacob Thyssen has participated in international and national advisory board meetings for Sanofi-Genzyme and Roche. Alexander Egeberg has received research funding from Pfizer and Eli Lilly, and honoraria as consultant and/or speaker from Pfizer, Eli Lilly, Novartis, Galderma, and Janssen Pharmaceuticals. Lone Skov has performed clinical trial for Regeneron, participated in advisory board meetings for Sanofi, and is supported by a grant from the Capital Region of Denmark, Foundation for Health Research.

This work was performed independently through the authors’ academic university and hospital affiliations.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

Figures

Fig. 1
Fig. 1
Putative role of tobacco smoking in the development of comorbidities associated with atopic dermatitis. The figure represents a simplified model of how tobacco smoking may influence the increased prevalence of comorbidities associated with atopic dermatitis. ADHD attention deficit hyperactivity disorder
See this image and copyright information in PMC

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