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Case Reports
. 2017 Jul;11(7):ED01-ED02.
doi: 10.7860/JCDR/2017/25261.10127. Epub 2017 Jul 1.

Clear Cell Adenocarcinoma of Female Urethra

Sharada Raju Rane  1 , Ashwini Nivrutti Ghodke  2 , Sharvari Vishwasrao  3
Affiliations
Case Reports

Clear Cell Adenocarcinoma of Female Urethra

Sharada Raju Rane et al. J Clin Diagn Res. 2017 Jul.

Abstract

Primary malignancies of female urethra are infrequent, constituting a fraction of less than 1% of genitourinary malignancies. Primary clear-cell adenocarcinoma of the urethra, is even rarer, that histomorphologically resembles clear-cell carcinoma of the female genital tract, occurs predominantly in women and is associated with a relatively poor prognosis. The histogenesis of this rare urethral neoplasm has not been completely determined. Various hypotheses concerning the origin have been postulated, including (1) diverticular origin (2) mullerian origin (3), glandular differentiation of urothelium or urothelial carcinoma. Here, we report a case of 67-year-old female with obstructive urinary symptoms and pain in abdomen, diagnosed with adenocarcinoma of urethra. Immunohistochemistry (IHC) workup of the tumour was done to find the origin of the tumour.

Keywords: Immunohistochemistry; Mullerian rests; Urethral Carcinoma; Urogenital Tract.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
Gross–ulcerative growth in urethra (arrow).
[Table/Fig-2]:
[Table/Fig-2]:
Scanner view of urethral clear cell adenocarcinoma (H&E 4X).
[Table/Fig-3]:
[Table/Fig-3]:
Urethral clear cell adenocarcinoma (H&E 10X); Inset –Hob nail pattern (H&E 40X).
[Table/Fig-4]:
[Table/Fig-4]:
Overlying free vaginal epithelium with underlying adenocarcinoma (H&E 4X).
[Table/Fig-5]:
[Table/Fig-5]:
CK7: Positive (IHC 4 X).
See this image and copyright information in PMC

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