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. 2017 Jul;11(7):ZF01-ZF05.
doi: 10.7860/JCDR/2017/26217.10169. Epub 2017 Jul 1.

Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study

Hossein Aghili  1 , Soghra Yassaei  2 , Shokouh Taghipour Zahir  3 , Rahele Arjmandi  4
Affiliations

Effect of Methylphenidate on Orthodontic Tooth Movement and Histological Features of Bone Tissue in Rats: An Experimental Study

Hossein Aghili et al. J Clin Diagn Res. 2017 Jul.

Abstract

Introduction: Methylphenidate is a psychostimulant drug, which is commonly used by children and teenagers. This age group receives most orthodontic treatment. Effect of this drug on tooth movement is unknown.

Aim: The aim of this study was to evaluate the effect of methylphenidate on orthodontic tooth movement and histological features of bone tissue in rats.

Materials and methods: Forty-two Wistar rats (male) were selected and divided to three groups, randomly (n=14). The control group (Group 1) received no drug, the experimental Group 2 received a constant dose of methylphenidate daily for 14 days while the experimental Group 3 received increasing doses of methylphenidate daily. To exert force, a NiTi coil spring was placed between the maxillary right first molar and the maxillary right central incisor. At the end of the study period, the amount of tooth movement was measured and then the rats were sacrificed for histological analysis of bone tissue. Differences between the experimental groups were analysed using Kruskal-wallis and Mann-Whitney U tests.

Results: No significant differences were found in the amount of orthodontic tooth movement or osteoclasts and lacunae, between the experimental groups (p>0.05). Mann-Whitney U analysis showed significant differences in the depth of resorption lacuna between Group 2 and 3 (p=0.037).

Conclusion: Methylphenidate has no significant effect on orthodontic tooth movement or histological features of bone tissue in rats.

Keywords: Osteoclast; Psychostimulant drug; Ritalin.

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Figures

[Table/Fig-1]:
[Table/Fig-1]:
Cervical grooves on the labia and distal surfaces of the right central incisor.
[Table/Fig-2]:
[Table/Fig-2]:
Application of nickel-titanium closed-coil spring.
[Table/Fig-3]:
[Table/Fig-3]:
Measurement of tooth movement using an interproximal filler gauge.
[Table/Fig-4]:
[Table/Fig-4]:
Interproximal filler gauge, which was calibrated in increments of 0.05 mm.
[Table/Fig-5]:
[Table/Fig-5]:
A histopathological section of the alveolar bone of rat upper first molar tooth (×40) showing osteoclasts and Howship’s lacunae (haematoxylin and eosin).
[Table/Fig-6a-c]:
[Table/Fig-6a-c]:
A histopathological section of the alveolar bone with exerted force (×40). a) Group 1; b) Group 2; c) Group 3.
[Table/Fig-6d-f]:
[Table/Fig-6d-f]:
A histopathological section of the alveolar bone without exerted force (×40) d) Group 1; e) Group 2; f) Group 3.
See this image and copyright information in PMC

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References

    1. Beyer C, Staunton C, Moodley K. The implications of methylphenidate use by healthy medical students and doctors in South Africa. BMC Med Ethics. 2014;15:20. - PMC - PubMed
    1. Carmack SA, Block CL, Howell KK, Anagnostaras SG. Methylphenidate enhances acquisition and retention of spatial memory. Neurosci Lett. 2014;567:45–50. - PubMed
    1. Aghili H, Moghadam MG, Yassaei S, Fattahi Meybodi AR, Ali Tabatabaei SM. Effect of tramadol at different doses on orthodontic tooth movement and bone resorption in rats. Dent Res J. 2013;10(3):337–42. - PMC - PubMed
    1. McCabe SE, Teter CJ, Boyd CJ. Medical use, illicit use and diversion of prescription stimulant medication. J Psychoactive Drugs. 2006;38(1):43–56. - PMC - PubMed
    1. Wilens TE, Adler LA, Adams J, Sgambati S, Rotrosen J, Sawtelle R, et al. Misuse and diversion of stimulants prescribed for ADHD: a systematic review of the literature. J Am Acad Child Adolesc Psychiatry. 2008;47(1):21–31. - PubMed

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