Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2017 Sep 11;17(1):242.
doi: 10.1186/s12872-017-0673-4.

Chronic kidney disease and diabetes associated with long-term outcomes in patients receiving percutaneous coronary intervention

Mao-Jen Lin  1   2 , Jung Lee  3   4 , Chun-Yu Chen  5   6 , Chia-Chen Huang  7 , Han-Ping Wu  8   9
Affiliations

Chronic kidney disease and diabetes associated with long-term outcomes in patients receiving percutaneous coronary intervention

Mao-Jen Lin et al. BMC Cardiovasc Disord. .

Abstract

Background: The effect of diabetes mellitus (DM) and chronic kidney disease (CKD) on long-term outcomes in patients receiving percutaneous coronary intervention (PCI) is unclear.

Methods: A total of 1394 patients who underwent PCI were prospectively enrolled and divided into 4 groups according to the presence or absence of DM or CKD. Baseline characteristics, risk factors, medications, and angiographic findings were compared. Determinants of long-term outcomes in patients undergoing PCI were analyzed.

Results: Patients with DM and CKD had the highest all-cause mortality and cardiovascular mortality (both P < 0.01) but there were no differences existed in myocardial infarction (MI) or repeated PCI among the 4 groups (P = 0.19, P = 0.87, respectively). Patients with DM and CKD had the lowest even-free rate of all-cause mortality, cardiovascular mortality, MI, and repeated PCI (P < 0.001, P < 0.001, P < 0.001, and P = 0.002, respectively). In the Cox proportional hazard model, patients with both DM and CKD had the highest risk of all-cause mortality (HR: 3.25, 95% CI: 1.85-5.59), cardiovascular mortality (HR: 3.58, 95% CI: 1.97-6.49), MI (HR: 2.43, 95% CI: 1.23-4.08), and repeated PCI (HR: 1.79, 95% CI: 1.33-2.41). Patients with CKD alone had the second highest risk of all-cause mortality (HR: 2.04, 95% CI: 1.15-3.63), cardiovascular mortality (HR: 2.13, 95% CI: 1.13-4.01), and repeated PCI (HR: 1.47, 95% CI: 1.09-1.97).

Conclusions: DM and CKD had additive effect on adverse long-term outcomes in patients receiving PCI; CKD was a more significant adverse predictor than DM.

Keywords: Chronic kidney disease; Diabetes mellitus; PCI.

PubMed Disclaimer

Conflict of interest statement

Ethics approval and consent to participate

The study protocol was approved by the Institution Review Board and ethics committee of Taichung Tzu Chi Hospital, Taiwan (REC104–19) and written inform consents were obtained from all participants..

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interest.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
a Cumulative ratio of freedom from recurrent MI among the 4 groups (P = 0.002). b Cumulative ratio of freedom from all death among the 4 groups (P < 0.001). c Cumulative ratio of freedom from CV death among the 4 groups (P < 0.001). d Cumulative ratio of freedom from Re-PCI among the 4 groups (P < 0.001)
See this image and copyright information in PMC

References

    1. Mathew V, Gersh BJ, Williams BA, Laskey WK, Willerson JT, et al. Outcomes in patients with diabetes mellitus undergoing percutaneous coronary intervention in the current era: a report from the prevention of REStenosis with Tranilast and its outcomes (PRESTO) trial. Circulation. 2004;109:476–480. doi: 10.1161/01.CIR.0000109693.64957.20. - DOI - PubMed
    1. Laskey WK, Seizer F, Viachos HA, Johnston J, Jacobs A, et al. Comparison of in-hospital and one-year outcomes in patients with and without diabetes mellitus undergoing percutaneous catheter intervention (from the national, heart, lung, and blood institute dynamic registry) Am J Cardiol. 2002;90:1062–1067. doi: 10.1016/S0002-9149(02)02770-4. - DOI - PubMed
    1. Best PJ, Berger PB, Davis BR, Grines CL, Sadeghi HM, PRESTO Investigators Impact of mild or moderate chronic kidney disease on the frequency of restenosis: results from the PRESTO trial. J Am Coll Cardiol. 2004;44:1786–1791. - PubMed
    1. Norhammar A, Lagerqvist B, Saleh N. Long-term mortality after PCI in patients with diabetes mellitus: results from the Swedish coronary angiography and angioplasty registry. EuroIntervention. 2010;5:891–897. doi: 10.4244/EIJV5I8A152. - DOI - PubMed
    1. Kaya E, Cuneo A, Hochadel M, Jünger C, Stepper W, et al. Impact of chronic kidney disease on the prognosis of patients undergoing percutaneous coronary interventions using drug-eluting stents. Clin Res Cardiol. 2011;100:1103–1109. doi: 10.1007/s00392-011-0347-7. - DOI - PubMed

MeSH terms