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Comparative Study
. 2017 Sep 11;17(1):77.
doi: 10.1186/s12905-017-0440-9.

Effect of periodontitis on the development of osteoporosis: results from a nationwide population-based cohort study (2003-2013)

Jung-Kyu Choi  1 , Young-Taek Kim  2 , Hye-In Kweon  2 , Eun-Cheol Park  3   4 , Seong-Ho Choi  5 , Jae-Hong Lee  6
Affiliations
Comparative Study

Effect of periodontitis on the development of osteoporosis: results from a nationwide population-based cohort study (2003-2013)

Jung-Kyu Choi et al. BMC Womens Health. .

Abstract

Background: The prevalence of osteoporosis associated with the aging process is anticipated to increase along with the rising aging population. Periodontitis that the most common chronic infections of humankind is considered the risk factor for osteoporosis. The aim of this study was to identify the association between osteoporosis and periodontitis using a population-based cohort.

Methods: The case group was defined as patients diagnosed with periodontitis and treated with subgingival curettage, root conditioning, periodontal flap operation, bone grafting for alveolar bone defects, and guided tissue regeneration. Case and control groups matched for gender, age, household income, type of social security, disability, and residential area were generated. A Cox proportional hazard model was constructed to examine the difference in the development of osteoporosis between the case and control groups. The final sample included 13,464 participants.

Results: The incidence of osteoporosis was 1.1% in males and 15.8% in females during a 10-year period. The risk factors for osteoporosis in males were increasing age and Charlson Comorbidity Index score. Periodontitis was not associated with the development of osteoporosis in males. The risk factors for osteoporosis in females were increasing age, body mass index, Charlson Comorbidity Index score, diabetes, and periodontitis. Women with periodontitis were more likely to also develop osteoporosis (HR: 1.22, 95% CI: 1.01-1.48).

Conclusions: Periodontitis has an effect on the development of osteoporosis in females. Managing good teeth is required for the prevention and delay of osteoporosis. This includes dental examinations, regular cleanings and gum treatment.

Keywords: Cohort study; Female; Middle-aged; Osteoporosis; Periodontitis.

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Conflict of interest statement

Ethics approval and consent to participate

All components and procedures of this study were approved by the Institutional Review Board (IRB) of the National Health Insurance Medical Center (NHIMC) (IRB File No.: NHIMC 2016–03-013). Our study utilized secondary data reported on the aggregate level, and each case in dataset was converted to prevent identification. So, it was not included informed consents of each patient.

Consent for publication

Not applicable.

Competing interests

The authors declare that they have no competing interests.

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Figures

Fig. 1
Fig. 1
Kaplan-Meier curves of subjects by gender and age-group over 11 years, according to presence of periodontitis
See this image and copyright information in PMC

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