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Review
. 2017 Sep 12;14(1):41.
doi: 10.1186/s12981-017-0170-y.

Modulation of the strength and character of HIV-specific CD8+ T cell responses with heteroclitic peptides

Kayla A Holder  1 , Michael D Grant  2
Affiliations
Review

Modulation of the strength and character of HIV-specific CD8+ T cell responses with heteroclitic peptides

Kayla A Holder et al. AIDS Res Ther. .

Abstract

Chronic infection with human immunodeficiency virus (HIV) causes HIV-specific CD8+ T cell dysfunction and exhaustion. The strong association between non-progression and maintenance of HIV-specific CD8+ T cell cytokine production and proliferative capacities suggests that invigorating CD8+ T cell immune responses would reduce viremia and slow disease progression. A series of studies have demonstrated that sequence variants of native immunogenic peptides can generate more robust CD8+ T cell responses and that stimulation with these 'heteroclitic' peptides can steer responses away from the phenotypic and functional attributes of exhaustion acquired during chronic HIV infection. Incorporation of heteroclitic peptide stimulation within therapeutic vaccines could favour induction of more effective cellular antiviral responses, and in combination with 'shock and kill' strategies, contribute towards HIV cure.

Keywords: CD8+ T cell; HIV; Heteroclitic; IFN-γ; IL-2; MHC; Peptide; Proliferation; T cell receptor; Therapeutic vaccine.

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References

    1. Borbulevych OY, Baxter TK, Yu Z, Restifo NP, Baker BM. Increased immunogenicity of an anchor-modified tumor-associated antigen is due to the enhanced stability of the peptide/MHC complex: implications for vaccine design. J Immunol (Baltimore, Md: 1950). 2005;174(8):4812–4820. doi: 10.4049/jimmunol.174.8.4812. - DOI - PMC - PubMed
    1. Cole DK, Edwards ES, Wynn KK, Clement M, Miles JJ, Ladell K, Ekeruche J, Gostick E, Adams KJ, Skowera A, et al. Modification of MHC anchor residues generates heteroclitic peptides that alter TCR binding and T cell recognition. J Immunol (Baltimore, Md: 1950). 2010;185(4):2600–2610. doi: 10.4049/jimmunol.1000629. - DOI - PMC - PubMed
    1. Price DA, Goulder PJ, Klenerman P, Sewell AK, Easterbrook PJ, Troop M, Bangham CR, Phillips RE. Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proc Natl Acad Sci USA. 1997;94(5):1890–1895. doi: 10.1073/pnas.94.5.1890. - DOI - PMC - PubMed
    1. Sun Y, Schmitz JE, Buzby AP, Barker BR, Rao SS, Xu L, Yang ZY, Mascola JR, Nabel GJ, Letvin NL. Virus-specific cellular immune correlates of survival in vaccinated monkeys after simian immunodeficiency virus challenge. J Virol. 2006;80(22):10950–10956. doi: 10.1128/JVI.01458-06. - DOI - PMC - PubMed
    1. Wherry EJ, Ha SJ, Kaech SM, Haining WN, Sarkar S, Kalia V, Subramaniam S, Blattman JN, Barber DL, Ahmed R. Molecular signature of CD8+ T cell exhaustion during chronic viral infection. Immunity. 2007;27(4):670–684. doi: 10.1016/j.immuni.2007.09.006. - DOI - PubMed

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