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Review
. 2017 Oct 19;372(1732):20160273.
doi: 10.1098/rstb.2016.0273.

Oncogenic human papillomaviruses

Alison A McBride  1
Affiliations
Review

Oncogenic human papillomaviruses

Alison A McBride. Philos Trans R Soc Lond B Biol Sci. .

Abstract

Human papillomaviruses (HPVs) are an ancient group of viruses with small, double-stranded DNA circular genomes. They are species-specific and have a strict tropism for mucosal and cutaneous stratified squamous epithelial surfaces of the host. A subset of these viruses has been demonstrated to be the causative agent of several human cancers. Here, we review the biology, natural history, evolution and cancer association of the oncogenic HPVs.This article is part of the themed issue 'Human oncogenic viruses'.

Keywords: HPV; cancer; keratinocyte; papillomavirus.

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Conflict of interest statement

I have no competing interests.

Figures

Figure 1.
Figure 1.
Viral genome. Map of an alpha-HPV genome. The URR (upstream regulatory region) contains the replication origin (ori). The early promoter (PE), late promoter (PL) and early and late polyadenylation sites (pAE and pAL) are indicated.
Figure 2.
Figure 2.
Oncogenic progression of cervical infection. Diagram of steps in progression from HPV infection to invasive cervical cancer.
Figure 3.
Figure 3.
Phylogenetic tree based on the L1 nucleotide sequence of HPVs. Group 1 oncogenic alpha-HPVs are shown in red, and Group 2 in orange.
Figure 4.
Figure 4.
Cancer statistics. (a) HPV-associated cancer incidence in the US 2008–2012 (data from Viens et al. [34]). (b) Distribution of oncogenic HPV types in different cancers (data from Saraiya et al. [35]). (c) Relative proportion of HPV-associated cancer cases based on gender (data from Viens et al. [34]).
See this image and copyright information in PMC

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