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Review
. 2017 Oct;31(5):883-895.
doi: 10.1016/j.hoc.2017.06.008.

Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

Geoffrey L Rogers  1 , Paula M Cannon  2
Affiliations
Review

Gene Therapy Approaches to Human Immunodeficiency Virus and Other Infectious Diseases

Geoffrey L Rogers et al. Hematol Oncol Clin North Am. 2017 Oct.

Abstract

Advances in gene therapy technologies, particularly in gene editing, are suggesting new avenues for the treatment of human immunodeficiency virus and other infectious diseases. This article outlines recent developments in antiviral gene therapies, including those based on the disruption of entry receptors or that target viral genomes using targeted nucleases, such as the CRISPR/Cas9 system. In addition, new ways to express circulating antiviral factors, such as antibodies, and approaches to harness and engineer the immune system to provide an antiviral effect that is not naturally achieved are described.

Keywords: AAV; Cas9; Gene editing; Gene therapy; HIV; Targeted nuclease.

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