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. 1987 Sep;24(9):544-6.
doi: 10.1136/jmg.24.9.544.

Linkage of the tuberous sclerosis locus to a DNA polymorphism detected by v-abl

J M Connor  1 , L A Pirrit, J R Yates, A E Fryer, M A Ferguson-Smith
Affiliations

Linkage of the tuberous sclerosis locus to a DNA polymorphism detected by v-abl

J M Connor et al. J Med Genet. 1987 Sep.

Abstract

Linkage analysis was undertaken in six families with tuberous sclerosis (TS) using a restriction fragment length polymorphism detected by v-abl. No recombinants were observed in 13 informative meioses (four phase known) giving a maximum lod score of 3.18 at zero recombination (confidence limits 0 to 0.15). This provides further evidence for the assignment of TS to 9q34 and should facilitate cloning of the structural gene, genetic counselling, and first trimester prenatal diagnosis.

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