Centrosome Biology: Polymer-Based Centrosome Maturation

Gagan D Gupta¹, Laurence Pelletier²

Affiliations

¹ Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.
² Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: pelletier@lunenfeld.ca.

PMID: 28898644
DOI: 10.1016/j.cub.2017.07.036

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Centrosome Biology: Polymer-Based Centrosome Maturation

Gagan D Gupta et al. Curr Biol. 2017.

Free article

. 2017 Sep 11;27(17):R836-R839.

doi: 10.1016/j.cub.2017.07.036.

Authors

Gagan D Gupta¹, Laurence Pelletier²

Affiliations

¹ Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada.
² Lunenfeld Tanenbaum Research Institute, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, M5G 1X5, Canada; Department of Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A8, Canada. Electronic address: pelletier@lunenfeld.ca.

PMID: 28898644
DOI: 10.1016/j.cub.2017.07.036

Abstract

The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur.

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The Centrosome Is a Selective Condensate that Nucleates Microtubules by Concentrating Tubulin.
Woodruff JB, Ferreira Gomes B, Widlund PO, Mahamid J, Honigmann A, Hyman AA. Woodruff JB, et al. Cell. 2017 Jun 1;169(6):1066-1077.e10. doi: 10.1016/j.cell.2017.05.028. Cell. 2017. PMID: 28575670
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Centrosome Biology: Polymer-Based Centrosome Maturation

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Centrosome Biology: Polymer-Based Centrosome Maturation

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