mRNAs on the Move after Lunch
- PMID: 28898674
- DOI: 10.1016/j.devcel.2017.08.017
mRNAs on the Move after Lunch
Abstract
mRNA localization often contributes to translational control. Reporting in Science, Moor et al. (2017) now show that many mRNAs and ribosomes are asymmetrically distributed along the apical-basal axis of enterocytes. Remarkably, when starved mice are fed, mRNAs encoding ribosomal proteins rapidly move to the ribosome-rich apical side to activate translation.
Copyright © 2017 Elsevier Inc. All rights reserved.
Comment on
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Global mRNA polarization regulates translation efficiency in the intestinal epithelium.Science. 2017 Sep 22;357(6357):1299-1303. doi: 10.1126/science.aan2399. Epub 2017 Aug 10. Science. 2017. PMID: 28798045 Free PMC article.
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