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Comment
. 2017 Sep 11;42(5):443-444.
doi: 10.1016/j.devcel.2017.08.023.

Developmental ERK Signaling Goes Digital

Coralie Dessauges  1 , Olivier Pertz  2
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Developmental ERK Signaling Goes Digital

Coralie Dessauges et al. Dev Cell. .
Free article

Abstract

Reporting in Developmental Cell, de la Cova et al. (2017) present a biosensor to measure ERK activity dynamics in C. elegans larvae. They find that fate decision signaling involves frequency-modulated, digital ERK activity pulses. These findings may explain how graded morphogen signals are converted into precise and robust cell fate patterns.

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