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. 2017 Nov;11(6):1772-1780.
doi: 10.1177/1557988317721642. Epub 2017 Sep 13.

The Role of Monocyte Percentage in Osteoporosis in Male Rheumatic Diseases

Yu-Jih Su  1 , Chao Tung Chen  2 , Nai-Wen Tsai  3 , Chih-Cheng Huang  3 , Hung-Chen Wang  4 , Chia-Te Kung  5 , Wei-Che Lin  6 , Ben-Chung Cheng  1   7 , Chih-Min Su  5 , Sheng-Yuan Hsiao  5   7 , Cheng-Hsien Lu  3   7   8
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The Role of Monocyte Percentage in Osteoporosis in Male Rheumatic Diseases

Yu-Jih Su et al. Am J Mens Health. 2017 Nov.

Abstract

Osteoporosis is easily overlooked in male patients, especially in the field of rheumatic diseases mostly prevalent with female patients, and its link to pathogenesis is still lacking. Attenuated monocyte apoptosis from a transcriptome-wide expression study illustrates the role of monocytes in osteoporosis. This study tested the hypothesis that the monocyte percentage among leukocytes could be a biomarker of osteoporosis in rheumatic diseases. Eighty-seven males with rheumatic diseases were evaluated in rheumatology outpatient clinics for bone mineral density (BMD) and surrogate markers, such as routine peripheral blood parameters and autoantibodies. From the total number of 87 patients included in this study, only 15 met the criteria for diagnosis of osteoporosis. Both age and monocyte percentage remained independently associated with the presence of osteoporosis. Steroid dose (equivalent prednisolone dose) was negatively associated with BMD of the hip area and platelet counts were negatively associated with BMD and T score of the spine area. Besides age, monocyte percentage meets the major requirements for osteoporosis in male rheumatic diseases. A higher monocyte percentage in male rheumatic disease patients, aged over 50 years in this study, and BMD study should be considered in order to reduce the risk of osteoporosis-related fractures.

Keywords: male; monocyte; osteoporosis; rheumatic diseases.

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Conflict of interest statement

Declaration of Conflicting Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Figure 1.
Figure 1.
Monocyte percentage distribution in each specific rheumatic disease.
See this image and copyright information in PMC

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