Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1987 Oct;84(20):7005-8.
doi: 10.1073/pnas.84.20.7005.

Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor

J Takeda  1 , Y Seino, K Tanaka, H Fukumoto, T Kayano, H Takahashi, T Mitani, M Kurono, T Suzuki, T Tobe, et al.
Affiliations
Comparative Study

Sequence of an intestinal cDNA encoding human gastric inhibitory polypeptide precursor

J Takeda et al. Proc Natl Acad Sci U S A. 1987 Oct.

Abstract

Gastric inhibitory polypeptide (GIP) is a 42-amino acid hormone that stimulates insulin secretion in the presence of glucose. Complementary DNA clones encoding human GIP were isolated from a library prepared with RNA from duodenum. The predicted amino acid sequence indicates that GIP is derived by proteolytic processing of a 153-residue precursor, preproGIP. The GIP moiety is flanked by polypeptide segments of 51 and 60 amino acids at its NH2 and COOH termini, respectively. The former includes a signal peptide of about 21 residues and an NH2-terminal propeptide of 30 amino acids. GIP is released from the precursor by processing at single arginine residues. There is a region of nine amino acids in the COOH-terminal propeptide of the GIP precursor that has partial homology with a portion of chromogranin A as well as pancreastatin.

PubMed Disclaimer

References

    1. Can J Physiol Pharmacol. 1969 Jan;47(1):113-4 - PubMed
    1. Nature. 1986 Dec 4-10;324(6096):476-8 - PubMed
    1. Gastroenterology. 1972 Mar;62(3):393-400 - PubMed
    1. Proc Natl Acad Sci U S A. 1972 Jun;69(6):1408-12 - PubMed
    1. Gut. 1973 Apr;14(4):284-8 - PubMed

Publication types

Associated data