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. 1987 Oct;84(20):7159-63.
doi: 10.1073/pnas.84.20.7159.

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

R M Hudziak  1 , J Schlessinger, A Ullrich
Affiliations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells

R M Hudziak et al. Proc Natl Acad Sci U S A. 1987 Oct.

Abstract

The HER2 gene encodes a cell-surface glycoprotein with extensive homology to the epidermal growth factor receptor. Recently it was found to be amplified in about 30% of primary human breast malignancies. In experiments designed to assess the role of the HER2 gene in oncogenesis, we found that overexpression of unaltered HER2 coding sequences in NIH 3T3 cells resulted in cellular transformation and tumorigenesis.

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References

    1. Cell. 1986 Jun 6;45(5):649-57 - PubMed
    1. EMBO J. 1987 Mar;6(3):605-10 - PubMed
    1. J Biol Chem. 1978 Mar 10;253(5):1357-70 - PubMed
    1. Virology. 1978 Nov;91(1):39-50 - PubMed
    1. Science. 1981 May 22;212(4497):941-3 - PubMed

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