Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2018 May 15;43(10):688-692.
doi: 10.1097/BRS.0000000000002413.

A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese

Yohei Takahashi  1   2 , Ikuyo Kou  1 , Yoji Ogura  1   2 , Atsushi Miyake  1   2 , Kazuki Takeda  1   2 , Masahiro Nakajima  1 , Shohei Minami  3 , Noriaki Kawakami  4 , Koki Uno  5 , Manabu Ito  6 , Ikuho Yonezawa  7 , Takashi Kaito  8 , Haruhisa Yanagida  9 , Kei Watanabe  10 , Hiroshi Taneichi  11 , Katsumi Harimaya  12 , Yuki Taniguchi  13 , Toshiaki Kotani  3 , Taichi Tsuji  4 , Teppei Suzuki  5 , Hideki Sudo  14 , Nobuyuki Fujita  2 , Mitsuru Yagi  2 , Kazuhiro Chiba  15 , Katsuki Kono  16 , Tsuyoshi Sakuma  3 , Tsutomu Akazawa  17 , Kotaro Nishida  18 , Kenichiro Kakutani  18 , Hideki Shigematsu  19 , Takahiro Iida  20 , Satoru Demura  21 , Naobumi Hosogane  15 , Eijiro Okada  22 , Masaya Nakamura  2 , Morio Matsumoto  2 , Kota Watanabe  2 , Shiro Ikegawa  1
Affiliations

A Replication Study for the Association of rs11190870 With Curve Severity in Adolescent Idiopathic Scoliosis in Japanese

Yohei Takahashi et al. Spine (Phila Pa 1976). .

Abstract

Study design: Case-only study.

Objective: The aim of this study was to confirm the association of rs11190870 with adolescent idiopathic scoliosis (AIS) severity in Japanese patients with AIS.

Summary of background data: Although the association of rs11190870 with AIS susceptibility is replicated in multiple ethnics, the association of rs11190870 with curve severity is controversial. Since the previous studies are of small, we performed a replication study using far larger number of patients than previous studies.

Methods: A total of 1860 Japanese patients with AIS who had reached skeletal maturity or undergone surgical fusion were included in the study. We evaluated the association between rs11190870 and AIS progression for the entire group, and then for patients grouped according to a severe curve (a Cobb angle of ≥40°) or mild curve (a Cobb angle <30°). Because braces could affect the results of the present study, patients in the mild-curve group were divided according to whether or not they had worn a brace. We then evaluated associations between rs11190870 genotype and curve severity in these groups.

Results: The mean Cobb angles were 54.8° ± 12.1° in the severe-curve group and 24.4° ± 4.0° in the mild-curve group. The difference in rs11190870 risk-allele frequency between the severe- and mild-curve groups was evaluated. No significant differences were observed. We then examined the association of rs11190870 risk-allele frequency between patients in the mild- and severe-curve groups using the χ test for three models, and found a marginal association between rs11190870 and curve severity in the dominant model (P = 0.035, odds ratio = 1.51).

Conclusion: We found no association between rs11190870 and curve severity using the criteria of previous study. However, we found a marginal association between rs11190870 and curve severity. Large-scale replication studies that consider skeletal maturity and brace history, including replication studies in other ethnic groups, would be helpful for clarifying the association.

Level of evidence: 4.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Weinstein SL, Dolan LA, Cheng JC, et al. Adolescent idiopathic scoliosis. Lancet 2008; 371:1527–1537.
    1. Wise CA, Gao X, Shoemaker S, et al. Understanding genetic factors in idiopathic scoliosis, a complex disease of childhood. Curr Genomics 2008; 9:51–59.
    1. Wu J, Qiu Y, Zhang L, et al. Association of estrogen receptor gene polymorphisms with susceptibility to adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 2006; 31:1131–1136.
    1. Zhang HQ, Lu SJ, Tang MX, et al. Association of estrogen receptor beta gene polymorphisms with susceptibility to adolescent idiopathic scoliosis. Spine (Phila Pa 1976) 2009; 34:760–764.
    1. Chen Z, Tang NL, Cao X, et al. Promoter polymorphism of matrilin-1 gene predisposes to adolescent idiopathic scoliosis in a Chinese population. Eur J Hum Genet 2009; 17:525–532.