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. 1987 Nov;41(5):944-7.

Linkage of DNA probe B79a (D7S13) to cystic fibrosis

B J Wainwright  1 , L C Tsui, M Leppert, M Buchwald, X Estivill, P O'Connell, M Lathrop, J M Lalouel, R White, R Williamson, et al.
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Linkage of DNA probe B79a (D7S13) to cystic fibrosis

B J Wainwright et al. Am J Hum Genet. 1987 Nov.

Abstract

We have conducted, in 64 affected families, a study of linkage between the anonymous DNA segment pB79a (D7S13) and the locus for cystic fibrosis (CF) on chromosome 7q. The maximum lod score was 12.60 at theta = .08 (confidence bounds .045-.135). Although D7S13 is not sufficiently close to CF for routine use in DNA-based prenatal diagnosis, it will be helpful in certain families when other nearby markers are uninformative. D7S13 will also be useful for refining the linkage map of the CF region.

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