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. 2017 Jul 18;8(33):55443-55452.
doi: 10.18632/oncotarget.19317. eCollection 2017 Aug 15.

Genetic variation and forensic characteristic analysis of 25 STRs of a novel fluorescence co-amplification system in Chinese Southern Shaanxi Han population

Yao-Shun Liu  1   2   3   4 , Jian-Gang Chen  1   5 , Ting Mei  1   2   3 , Yu-Xin Guo  2   3 , Hao-Tian Meng  2   3 , Jian-Fei Li  6 , Yuan-Yuan Wei  2   3 , Xiao-Ye Jin  2   3 , Bo-Feng Zhu  2   3   4 , Li-Ping Zhang  1
Affiliations

Genetic variation and forensic characteristic analysis of 25 STRs of a novel fluorescence co-amplification system in Chinese Southern Shaanxi Han population

Yao-Shun Liu et al. Oncotarget. .

Abstract

We analyzed the genetic polymorphisms of 15 autosomal and 10 Y-chromosomal STR loci in 214 individuals of Han population from Southern Shaanxi of China and studied the genetic relationships between Southern Shaanxi Han and other populations. We observed a total of 150 alleles at 15 autosomal STR loci with the corresponding allelic frequencies ranging from 0.0023 to 0.5210, and the combined power of discrimination and exclusion for the 15 autosomal STR loci were 0.99999999999999998866 and 0.999998491, respectively. For the 10 Y-STR loci, totally 100 different haplotypes were obtained, of which 94 were unique. The discriminatory capacity and haplotype diversity values of the 10 Y-STR loci were 0.9259 and 0.998269, respectively. The results demonstrated high genetic diversities of the 25 STR loci in the population for forensic applications. We constructed neighbor-joining tree and conducted principal component analysis based on 15 autosomal STR loci and conducted multidimensional scaling analysis and constructed neighbor-joining tree based on 10 Y-STR loci. The results of population genetic analyses based on both autosomal and Y-chromosome STRs indicated that the studied Southern Shaanxi Han population had relatively closer genetic relationship with Eastern Han population, and distant relationships with Croatian, Serbian and Moroccan populations.

Keywords: Southern Shaanxi Han population; Y-STR; autosomal STR; forensic characteristic analysis; genetic polymorphisms.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors state that they have no conflicts of interest.

Figures

Figure 1
Figure 1. Principal component analysis based on the 15 overlapping autosomal STR loci of Southern Shaanxi Han population and 19 reference populations
Figure 2
Figure 2. The neighbor-joining tree based on the 15 overlapping autosomal STR loci of Southern Shaanxi Han population and 19 reference populations
Figure 3
Figure 3. Multidimensional scaling analysis plot of the 20 populations based on the 10 overlapping Y-STR loci
Figure 4
Figure 4. The neighbor-joining tree based on the 10 overlapping Y-STR loci of Southern Shaanxi Han population and 19 reference populations
See this image and copyright information in PMC

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