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. 2017 Jun 21;8(33):55489-55510.
doi: 10.18632/oncotarget.18590. eCollection 2017 Aug 15.

Prognostic value of microRNAs in gastric cancer: a meta-analysis

Yue Zhang  1 , Dong-Hui Guan  2 , Rong-Xiu Bi  2 , Jin Xie  2 , Chuan-Hua Yang  3 , Yue-Hua Jiang  4
Affiliations

Prognostic value of microRNAs in gastric cancer: a meta-analysis

Yue Zhang et al. Oncotarget. .

Abstract

Background: Previous articles have reported that expression levels of microRNAs (miRNAs) are associated with survival time of patients with gastric cancer (GC). A systematic review and meta-analysis was performed to study the outcome of it.

Design: Meta-analysis.

Methods: English studies estimating expression levels of miRNAs with any of survival curves in GC were identified up till March 19, 2017 through performing online searches in PubMed, EMBASE, Web of Science and Cochrane Database of Systematic Reviews by two authors independently. The pooled hazard ratios (HR) with 95% confidence intervals (CI) were used to estimate the correlation between miRNA expression and overall survival (OS).

Results: Sixty-nine relevant articles about 26 miRNAs with 6148 patients were ultimately included. GC patients with high expression of miR-20b (HR=2.38, 95%CI=1.16-4.87), 21 (HR=1.77, 95%CI=1.01-3.08), 106b (HR=1.84, 95%CI=1.15-2.94), 196a (HR=2.66, 95%CI=1.94-3.63), 196b (HR=1.67, 95%CI=1.38-2.02), 214 (HR=1.84, 95%CI=1.27-2.67) or low expression of miR-125a (HR=2.06, 95%CI=1.26-3.37), 137 (HR=3.21, 95%CI=1.68-6.13), 141 (HR=2.47, 95%CI=1.34-4.56), 145 (HR=1.62, 95%CI=1.07-2.46), 146a (HR=2.60, 95%CI=1.63-4.13), 206 (HR=2.85, 95%CI=1.73-4.70), 218 (HR=2.61, 95%CI=1.74-3.92), 451 (HR=1.73, 95%CI=1.19-2.52), 486-5p (HR=2.45, 95%CI=1.65-3.65), 506 (HR=2.07, 95%CI=1.33-3.23) have significantly poor OS (P<0.05).

Conclusions: In summary, miR-20b, 21, 106b, 125a, 137, 141, 145, 146a, 196a, 196b, 206, 214, 218, 451, 486-5p and 506 demonstrate significantly prognostic value. Among them, miR-20b, 125a, 137, 141, 146a, 196a, 206, 218, 486-5p and 506 are strong biomarkers of prognosis in GC.

Keywords: gastric cancer; meta-analysis; microRNA; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1. Flow diagram of literature search and selection
Figure 2
Figure 2
(A) Forest plot of the analyses about high expression of miR-21 and RFS/CSS or OS; (B) Publication bias of the analysis about high expression of miR-21 and OS; (C) Sensitivity analysis of the study about high expression of miR-21 and OS; and (D) Forest plot of the analyses about low expression of miR-34a and OS or OS (multivariate analysis).
Figure 3
Figure 3. Forest plot of the analyses about high expression of miR-20a, 20b, 106b, 107 or low expression of miR-27b and OS
Figure 4
Figure 4. Forest plot of the analyses about high expression of miR-143 or low expression of miR-125a, 137, 141, 145 and OS
Figure 5
Figure 5. Forest plot of the analyses about high expression of miR-150, 192 or low expression of miR-146a, 183 and OS or RFS/PFS
Figure 6
Figure 6. Forest plot of the analyses about high expression of miR-196a, 196b or low expression of miR-200c and OS or PFS/DFS
Figure 7
Figure 7. Forest plot of the analyses about high expression of miR-214 or low expression of miR-206, 218, 335 and OS
Figure 8
Figure 8. Forest plot of the analyses about low expression of miR-451, 486-5p, 506 and OS or DFS/RFS
See this image and copyright information in PMC

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