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Review
. 2017 Jan 18;8(33):55613-55621.
doi: 10.18632/oncotarget.14732. eCollection 2017 Aug 15.

Positive expression of Y-box binding protein 1 and prognosis in non-small cell lung cancer: a meta-analysis

Liang Jiang  1 , Gao-Le Yuan  1 , Qi-Lian Liang  1 , Hui-Jie Zhang  1 , Jie Huang  1 , Shao-Ang Cheng  1 , Xiao-Xia Peng  1
Affiliations
Review

Positive expression of Y-box binding protein 1 and prognosis in non-small cell lung cancer: a meta-analysis

Liang Jiang et al. Oncotarget. .

Abstract

Background: Y-box binding protein 1 (YB-1) belongs to the cold shock domain protein family involved in transcription and translation. We conducted a meta-analysis of the association between YB-1 expression and the survival and clinicopathological features in NSCLC.

Methods: PubMed and Embase were searched to identify studies that evaluated the YB-1 expression (by immunohistochemistry) and overall survival (OS) in NSCLC. Hazard ratios (HRs) and 95% confidence intervals (CI) of OS were pooled. Odds ratios (ORs) of clinicopathological features were computed. Meta-analysis was performed using STATA 12.0 software.

Results: Data on 692 NSCLC patients were collected from six eligible studies. Meta-analysis revealed that YB-1 was associated with worse OS (HR = 1.59, 95% CI [1.27, 2.00], P < 0.001, fixed effect), tumor stage (OR = 0.43, 95% CI [0.22-0.82], P = 0.01, random effect), and depth of invasion (OR = 0.37, 95%CI [0.22-0.63], P < 0.001, fixed effect). A subgroup was analyzed by IHC staining to determine the location of YB-1 positive expression. Poor OS was observed in nucleus staining (pooled HR = 1.86, 95% CI [1.41, 2.45], P < 0.001). However, no statistical significance was observed in combined cytoplasmic and nuclear staining (pooled HR = 1.14, 95% CI [0.76, 1.72], P = 0.536).

Conclusions: Meta-analysis indicated that YB-1 overexpression is correlated with worse OS and clinicopathological features in NSCLC. Subgroup analysis revealed that the nucleus expression of YB-1 may be more closely associated with NSCLC prognosis than cytoplasmic expression.

Keywords: IHC; NSCLC; YB-1; meta-analysis; prognosis.

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Conflict of interest statement

CONFLICTS OF INTEREST The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1. Flow chart for selection of studies
Figure 2
Figure 2. Forest plot showing the HR of YB-1 overexpression vs. normal YB-1 expression for OS
The weight of each study in the meta-analysis is illustrated by the size of squares, and the extending line crossing the square illustrates the 95% CI. The diamond represents the pooled HR performed by the fixed-effect model.
Figure 3
Figure 3. Forest plots showing the OR of YB-1 overexpression vs. normal YB-1 expression for clinicopathological features
A. Age B. Sex C. Tumor differentiation D. Lymph node metastasis E. Histology F. Tumor stage G. Depth of invasion. All pooled ORs were obtained by using a fixed-effect model except for figure marked with (NOTE: Weights are from random effects analysis).
Figure 4
Figure 4. Effect of individual studies on the pooled HR forYB-1 overexpression and OS of NSCLC
The horizontal axis number 1.59 represents the overall HR, and the 1.27 and 2.00 represent the 95% CI.
See this image and copyright information in PMC

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