Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines

Lindsay Kim¹, Brian Rha¹, Jon S Abramson², Larry J Anderson³, Carrie L Byington⁴, Grace L Chen⁵, John DeVincenzo^{6

7

8}, Kathryn M Edwards⁹, Janet A Englund¹⁰, Ann R Falsey¹¹, Marie R Griffin^{12

13

14}, Ruth A Karron¹⁵, Karen G Martin^{16

17}, H Cody Meissner¹⁸, Flor M Munoz¹⁹, Andrew T Pavia²⁰, Pedro A Piedra¹⁹, William Schaffner²¹, Eric A F Simões^{22

23}, Rosalyn Singleton^{24

25}, H Keipp Talbot²⁶, Edward E Walsh¹¹, Jane R Zucker^{27

28}, Susan I Gerber¹

Affiliations

¹ Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
² Wake Forest School of Medicine, Winston-Salem, North Carolina.
³ Department of Pediatrics, Emory University, Atlanta, Georgia.
⁴ College of Medicine, Texas A&M University, Bryan.
⁵ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
⁶ Pediatrics.
⁷ Microbiology, Immunology, and Biochemistry, University of Tennessee Center for Health Sciences.
⁸ Children's Foundation Research Institute, Lebonheur Children's Hospital, Memphis.
⁹ Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
¹⁰ Department of Pediatrics, University of Washington, Seattle.
¹¹ Department of Medicine, University of Rochester School of Medicine, New York.
¹² Health Policy.
¹³ Medicine, Vanderbilt University Medical Center.
¹⁴ Mid-South Geriatric Research Education and Clinical Center, VA Tennessee Valley Health Care System, Nashville.
¹⁵ Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
¹⁶ Council of State and Territorial Epidemiologists, Atlanta, Georgia.
¹⁷ Minnesota Department of Health, St Paul.
¹⁸ Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts.
¹⁹ Departments of Pediatrics, Molecular Virology, and Microbiology, Baylor College of Medicine, Houston, Texas.
²⁰ Departments of Pediatrics and Medicine, University of Utah School of Medicine, Salt Lake City.
²¹ Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
²² Department of Pediatrics, University of Colorado School of Medicine.
²³ Department of Epidemiology, Center for Global Health, Colorado School of Public Health, Aurora.
²⁴ Alaska Native Tribal Health Consortium.
²⁵ Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage.
²⁶ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
²⁷ New York City Department of Health and Mental Hygiene, Bureau of Immunization.
²⁸ Immunization Services Division, Centers for Disease Control and Prevention, Atlanta, Georgia.

PMID: 28903503
PMCID: PMC5850021
DOI: 10.1093/cid/cix432

Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines

Lindsay Kim et al. Clin Infect Dis. 2017.

. 2017 Sep 15;65(6):1020-1025.

doi: 10.1093/cid/cix432.

Authors

Affiliations

¹ Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia.
² Wake Forest School of Medicine, Winston-Salem, North Carolina.
³ Department of Pediatrics, Emory University, Atlanta, Georgia.
⁴ College of Medicine, Texas A&M University, Bryan.
⁵ Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland.
⁶ Pediatrics.
⁷ Microbiology, Immunology, and Biochemistry, University of Tennessee Center for Health Sciences.
⁸ Children's Foundation Research Institute, Lebonheur Children's Hospital, Memphis.
⁹ Department of Pediatrics, Vanderbilt University School of Medicine, Nashville, Tennessee.
¹⁰ Department of Pediatrics, University of Washington, Seattle.
¹¹ Department of Medicine, University of Rochester School of Medicine, New York.
¹² Health Policy.
¹³ Medicine, Vanderbilt University Medical Center.
¹⁴ Mid-South Geriatric Research Education and Clinical Center, VA Tennessee Valley Health Care System, Nashville.
¹⁵ Center for Immunization Research, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
¹⁶ Council of State and Territorial Epidemiologists, Atlanta, Georgia.
¹⁷ Minnesota Department of Health, St Paul.
¹⁸ Department of Pediatrics, Tufts University School of Medicine, Boston, Massachusetts.
¹⁹ Departments of Pediatrics, Molecular Virology, and Microbiology, Baylor College of Medicine, Houston, Texas.
²⁰ Departments of Pediatrics and Medicine, University of Utah School of Medicine, Salt Lake City.
²¹ Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.
²² Department of Pediatrics, University of Colorado School of Medicine.
²³ Department of Epidemiology, Center for Global Health, Colorado School of Public Health, Aurora.
²⁴ Alaska Native Tribal Health Consortium.
²⁵ Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage.
²⁶ Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee.
²⁷ New York City Department of Health and Mental Hygiene, Bureau of Immunization.
²⁸ Immunization Services Division, Centers for Disease Control and Prevention, Atlanta, Georgia.

PMID: 28903503
PMCID: PMC5850021
DOI: 10.1093/cid/cix432

Abstract

Respiratory syncytial virus (RSV) causes lower respiratory tract illness frequently. No effective antivirals or vaccines for RSV are approved for use in the United States; however, there are at least 50 vaccines and monoclonal antibody products in development, with those targeting older adults and pregnant women (to protect young infants) in phase 2 and 3 clinical trials. Unanswered questions regarding RSV epidemiology need to be identified and addressed prior to RSV vaccine introduction to guide the measurement of impact and future recommendations. The Centers for Disease Control and Prevention (CDC) convened a technical consultation to gather input from external subject matter experts on their individual perspectives regarding evidence gaps in current RSV epidemiology in the United States, potential studies and surveillance platforms needed to fill these gaps, and prioritizing efforts. Participants articulated their individual views, and CDC staff synthesized individuals' input into this report.

Keywords: epidemiology; monoclonal antibody; respiratory syncytial virus; vaccine; vaccine impact.

Published by Oxford University Press for the Infectious Diseases Society of America 2017. This work is written by (a) US Government employee(s) and is in the public domain in the US.

PubMed Disclaimer

References

1. Nair H, Nokes DJ, Gessner BD et al. . Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis. Lancet 2010; 375:1545–55. - PMC - PubMed
1. Hall CB, Weinberg GA, Iwane MK et al. . The burden of respiratory syncytial virus infection in young children. N Engl J Med 2009; 360:588–98. - PMC - PubMed
1. Jain S, Finelli L; CDC EPIC Study Team Community-acquired pneumonia among U.S. children. N Engl J Med 2015; 372:2167–8. - PMC - PubMed
1. Falsey AR, Hennessey PA, Formica MA, Cox C, Walsh EE. Respiratory syncytial virus infection in elderly and high-risk adults. N Engl J Med 2005; 352:1749–59. - PubMed
1. Nicholson KG, Kent J, Hammersley V, Cancio E. Acute viral infections of upper respiratory tract in elderly people living in the community: comparative, prospective, population based study of disease burden. BMJ 1997; 315:1060–4. - PMC - PubMed

Publication types

Actions

MeSH terms

Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions
Actions

Substances

Actions

LinkOut - more resources

Full Text Sources
Other Literature Sources
- scite Smart Citations
Medical
- ClinicalTrials.gov
- MedlinePlus Health Information

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines

Affiliations

Identifying Gaps in Respiratory Syncytial Virus Disease Epidemiology in the United States Prior to the Introduction of Vaccines

Authors

Affiliations

Abstract

References

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical