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. 2017 Sep 1;6(3):e149-e151.
doi: 10.1093/jpids/pix058.

Retrospective Analysis of Posaconazole Suspension Dosing Strategies in a Pediatric Oncology Population: Single-Center Experience

Sherry Mathew  1 , Michelle L Kussin  1 , Dazhi Liu  1 , Melissa Pozotrigo  1 , Brian Seyboth  1 , Jennifer Thackray  1 , Shirley Qiong Yan  1 , Meier Hsu  2 , Nina Cohen  1 , Susan K Seo  3
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Retrospective Analysis of Posaconazole Suspension Dosing Strategies in a Pediatric Oncology Population: Single-Center Experience

Sherry Mathew et al. J Pediatric Infect Dis Soc. .

Abstract

Limited data on optimal posaconazole dosing strategies for pediatric patients exist. In this study, we found that the median initial dose in patients who achieved a posaconazole plasma concentration of 0.7 μg/mL was 22.8 mg/kg per day whereas the median initial dose in those who did not reach the target concentration was 15.8 mg/kg per day; this result suggests that higher initial doses might be warranted.

Keywords: oncology; pediatrics; posaconazole.

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