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Review
. 2017 Sep 1;6(3):e123-e133.
doi: 10.1093/jpids/pix059.

Fungal Infections of the Central Nervous System in Children

Matthew W McCarthy  1 , Darius Kalasauskas  2   3 , Vidmantas Petraitis  3   4 , Ruta Petraitiene  3   4 , Thomas J Walsh  3   5
Affiliations
Review

Fungal Infections of the Central Nervous System in Children

Matthew W McCarthy et al. J Pediatric Infect Dis Soc. .

Abstract

Although uncommon in children, fungal infections of the central nervous system can be devastating and difficult to treat. A better understanding of basic mycologic, immunologic, and pharmacologic processes has led to important advances in the diagnosis and management of these diseases, but their mortality rates remain unacceptably high. In this focused review, we examine the epidemiology and clinical features of the most common fungal pathogens of the central nervous system in children and explore recent advances in diagnosis and antifungal therapy.

Keywords: CNS; Candida meningoencephalitis; aspergillosis; cryptococcosis; fungal infections; mucormycosis.

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